Structure of PDB 7s0t Chain A Binding Site BS02

Receptor Information
>7s0t Chain A (length=1231) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SDYFRIQLNNQDYYMSKPTFLDPSHGESLPLNQFSQVPNIRVFGALPTGH
QVLCHVHGILPYMFIKYDGQITDTSTLRHQRCAQVHKTLEVKIRASFKKL
GNLNFVADVSVVKGIPFYGYHVGWNLFYKISLLNPSCLSRISELIRDGKI
FGKKFEIYESHIPYLLQWTADFNLFGCSWINVDRCYFRSPVLNSILDIDK
LTINDDLQLLLDRFCDFKCNVLSRRDFPRVGNGLIEIDILPQFIKNREKL
QHRDIHHDFLEKLGKPYVSSARDMINELTMQREYKEPPETKRHVSGHQWQ
SSGEFEAFYKKAQHKTSTIPNFENFIDKQKFSAINTPYEALPQLWPRLPQ
IEAGLRYGKRAFVYGEPPFGYQDILNKLEDEGFPKIDYKDPFFSNPVDLE
NKPYAYAGKRFEISSTHVSTRIPVQFGGETVSVYNKPTFDMFSSWKYALK
PPTYDAVQKWYNKVPSSVHDSLTHLTLEIHANTRSDKIPDPAIDEVSMII
WCLEEETFPLDLDIAYEGIMIVHKADSTFPTKIQHCINEIPVMFYESEFE
MFEALTDLVLLLDPDILSGFEIHNFSWGYIIERCQKIHQFDIVRELARVK
CSDTWGYAHSSGIMITGRHMINIWRALRSDVNLTQYTIESAAFNILHKRL
PHFSFESLTNMWNAKKSTTELKTVLNYWLSRAQINIQLLRKQDYIARNIE
QARLIGIDFHSVYYRGSQFKVESFLIRICKSESFILLSPGKKDVRKQKAL
ECVPLVMEPESAFYKSPLIVLDFQSLYPSIMIGYNYCYSTMIGRVREINL
TENNLGVSKFSLPRNILALLKNDVTIAPNGVVYAKTSVRKSTLSKMLTDI
LDVRVMIKKTMTTLKRLLNNKQLALKLLANVTYGYTSASFSGRMPCSDLA
DSIVQTGRETLEKAIDIIEKDETWNAKVVYGDTDSLFVYLPGKTAIEAFS
IGHAMAERVTQNNPKPIFLKFEKVYHPSILISKKRYVGFSYESPSQTLPI
FDAKGIETVRRDGIPAQQKIIEKCIRLLFQTKDLSKIKKYLQNEFFKIQI
GKVSAQDFCFAKEVKLGAYKSEKTAPAGAVVVKRRINAEPQYKERIPYLV
VKQLLRCVSPEFLEGLDSEYYINKILIPPLDRLFNLIGINVGNWAQEIKR
STTTLSFLIKKLKRQKEYQTLKTVCRTCSYRYTSDAGIENDHIASKCNSY
DCPVFYSRVKAERYLRDNQSVQREEALISLN
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7s0t Cryo-EM structure of translesion DNA synthesis polymerase zeta with a base pair mismatch.
Resolution3.05 Å
Binding residue
(original residue number in PDB)		W808 R918 G919 Q921 V956 G1094 S1097 F1100 K1193 R1195 L1322 L1323 R1324 R1357
Binding residue
(residue number reindexed from 1)		W605 R715 G716 Q718 V753 G884 S887 F890 K983 R985 L1104 L1105 R1106 R1132
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0046872 metal ion binding
GO:0051539 4 iron, 4 sulfur cluster binding
Biological Process
GO:0000724 double-strand break repair via homologous recombination
GO:0006260 DNA replication
GO:0006281 DNA repair
GO:0006974 DNA damage response
GO:0019985 translesion synthesis
GO:0042276 error-prone translesion synthesis
GO:0070987 error-free translesion synthesis
Cellular Component
GO:0005634 nucleus
GO:0005739 mitochondrion
GO:0016035 zeta DNA polymerase complex
GO:0043231 intracellular membrane-bounded organelle

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7s0t, PDBe:7s0t, PDBj:7s0t
PDBsum7s0t
PubMed35217661
UniProtP14284|DPOZ_YEAST DNA polymerase zeta catalytic subunit (Gene Name=REV3)

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