Structure of PDB 7rhw Chain A Binding Site BS02

Receptor Information

>7rhw Chain A (length=437) Species: 330879 (Aspergillus fumigatus Af293)

PISKIHARSVYDSRGNPTVEVDVVTETGLHRAIVPSGASTGQHEAHELRD
GDKTQWGGKGVLKAVKNVNETIGPALIKENIDVKDQSKVDEFLNKLDGTA
NKSNLGANAILGVSLAVAKAGAAEKGVPLYAHISDLAGTKKPYVLPVPFQ
NVLNGGSHAGGRLAFQEFMIVPDSAPSFSEALRQGAEVYQKLKALAKKKY
GQSAGNVGDEGGVAPDIQTAEEALDLITEAIEQAGYTGKIKIAMDVASSE
FYKADVKKYDLDFKNPESDPSKWLTYEQLADLYKSLAAKYPIVSIEDPFA
EDDWEAWSYFYKTSDFQIVGDDLTVTNPGRIKKAIELKSCNALLLKVNQI
GTLTESIQAAKDSYADNWGVMVSHRSGETEDVTIADIAVGLRSGQIKTGA
PCRSERLAKLNQILRIEEELGENAVYAGSKFRTAVNL

Ligand information

• Ligand ID: MG
• InChI: InChI=1S/Mg/q+2
• InChIKey: JLVVSXFLKOJNIY-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mg+2]
  CACTVS 3.341: [Mg++]
• Formula: Mg
• Name: MAGNESIUM ION
• DrugBank: DB01378
• PDB chain: 7rhw Chain A Residue 502

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7rhw A structural model of the human plasminogen and Aspergillus fumigatus enolase complex.
• Resolution: 1.9 Å
• Binding residue (original residue number in PDB): D246 E297 D322
• Binding residue (residue number reindexed from 1): D245 E296 D321
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 4.2.1.11: phosphopyruvate hydratase.

Gene Ontology

Molecular Function

• GO:0000287 magnesium ion binding
• GO:0004634 phosphopyruvate hydratase activity
• GO:0016829 lyase activity
• GO:0019863 IgE binding
• GO:0046872 metal ion binding

Biological Process

• GO:0006096 glycolytic process

Cellular Component

• GO:0000015 phosphopyruvate hydratase complex
• GO:0005737 cytoplasm

External links

• PDB: RCSB:7rhw, PDBe:7rhw, PDBj:7rhw
• PDBsum: 7rhw
• PubMed: 35247004
• UniProt: Q96X30|ENO_ASPFU Enolase (Gene Name=enoA)