Structure of PDB 7rfk Chain A Binding Site BS02

Receptor Information
>7rfk Chain A (length=568) Species: 272563 (Clostridioides difficile 630) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QDNFLLSKEYENSLDVDTKKASGIYYTPKIIVDYIVKKTLKNHDIIKNPY
PRILDISCGCGNFLLEVYDILYDLFEENIYELKKKYDENYWTVDNIHRHI
LNYCIYGADIDEKAISILKDSLTNKKVVESDIKINLFCCDSLKKKWRYKF
DYIVGNPPYIGHKKLEKKYKKFLLEKYSEVYKDKADLYFCFYKKIIDILK
QGGIGSVITPRYFLESLSGKDLREYIKSNVNVQEIVDFLGANIFKNIGVS
SCILTFDKKKTKETYIDVFKIKNEDICINKFETLEELLKSSKFEHFNINQ
RLLSDEWILVNKDDETFYNKIQEKCKYSLEDIAISFQGIITGCDKAFILS
KDDVKLNLVDDKFLKCWIKSKNINKYIVDKSEYRLIYSNDIDNENTNKRI
LDEIIGLYKTKLENRRECKSGIRKWYELQWGREKLFFERKKIMYPYKSNE
NRFAIDYDNNFSSADVYSFFIKEEYLDKFSYEYLVGILNSSVYDKYFKIT
AKKMSKNIYDYYPNKVMKIRIFRDNNYEEIENLSKQIISILLNKSIDKGK
VEKLQIKMDNLIMDSLGI
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7rfk Repurposing epigenetic inhibitors to target the Clostridioides difficile- specific DNA adenine methyltransferase and sporulation regulator CamA.
Resolution2.05 Å
Binding residue
(original residue number in PDB)		K25 Y30 N165 P166 Y168 K193 Y221 S227 F253 I256 G257 Q346 W439 R441 K456 Y476 K511 M513 Y521 P522 N523
Binding residue
(residue number reindexed from 1)		K20 Y25 N156 P157 Y159 K184 Y212 S218 F244 I247 G248 Q337 W430 R432 K447 Y467 K502 M504 Y512 P513 N514
Enzymatic activity
Enzyme Commision number 2.1.1.72: site-specific DNA-methyltransferase (adenine-specific).
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0008168 methyltransferase activity
GO:0009007 site-specific DNA-methyltransferase (adenine-specific) activity
Biological Process
GO:0006304 DNA modification
GO:0032259 methylation

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Molecular Function
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Biological Process
External links
PDB RCSB:7rfk, PDBe:7rfk, PDBj:7rfk
PDBsum7rfk
PubMed34523387
UniProtQ183J3

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