Structure of PDB 7rd6 Chain A Binding Site BS02

Receptor Information
>7rd6 Chain A (length=929) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EREIHPDTTPVYDRNRYVSNELSNAKYNAVTFVPTLLYEQFKFFYNLYFL
VVALSQAVPALRIGYLSSYIVPLAFVLTVTMAKEAIDDIQRRRRDRESNN
ELYHVITRNRSIPSKDLKVGDLIKVHKGDRIPADLVLLQSSEPSGESFIK
TDQLDGETDWKLRVACPLTQNLINRISITASAPEKSIHKFLGKVTYKDST
SNPLSVDNTLWANTVLASSGFCIACVVYTGRDTRQAMNTTTAKVKTGLLE
LEINSISKILCACVFALSILLVAFAGFHNDDWYIDILRYLILFSTIIPVS
LRVNLDLAKSVYAHQIEHDKTIPETIVRTSTIPEDLGRIEYLLSDKTGTL
TQNDMQLKKIHLGTVSYTSETLDIVSDYVQSLVKDMSFRVRDMILTLAIC
HNVTPTFEDDELTYQAASPDEIAIVKFTESVGLSLFKRDRHSISLLHEHS
GKTLNYEILQVFPFNSDSKRMGIIVRDEQLDEYWFMQKGADTVMSKIVES
NDWLEEETGNMAREGLRTLVIGRKKLNKKIYEQFQKEITKYLEHDLELLG
LTGVEDKLQKDVKSSIELLRNAGIKIWMLTGDKVETARCVSISAKLISRG
QYVHTITKVACLLIDGESLGMFLKHYEQEFFDVVVHLPTVIACRCTPQQK
ADVALVIRKMTGKRVCCIGDGGNDVSMIQCADVGVGIVGKEGKQASLAAD
FSITQFCHLTELLLWHGRNSYKRSAKLAQFVMHRGLIIAICQAVYSICSL
FEPIALYQGWLMVGYATCYTMAPVFSLTLDHDIEESLTKIYPELYKELTE
GKSLSYKTFFVWVLLSLFQGSVIQLFSQAFTSLLDTDFTRMVAISFTALV
VNELIMVALEIYTWNKTMLVTEIATLLFYIVSVPFLGDYFDLGYMTTVNY
YAGLLVILLISIFPVWTAKAIYRRLHPPS
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain7rd6 Chain A Residue 1202 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7rd6 Structural basis of the P4B ATPase lipid flippase activity.
Resolution3.25 Å
Binding residue
(original residue number in PDB)		D882 N885
Binding residue
(residue number reindexed from 1)		D670 N673
Annotation score1
Enzymatic activity
Enzyme Commision number 7.6.2.1: P-type phospholipid transporter.
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0000287 magnesium ion binding
GO:0005215 transporter activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity
GO:0046872 metal ion binding
GO:0090555 phosphatidylethanolamine flippase activity
GO:0090556 phosphatidylserine floppase activity
GO:0140326 ATPase-coupled intramembrane lipid transporter activity
GO:0140346 phosphatidylserine flippase activity
GO:0180013 lysophosphatidylserine flippase activity
Biological Process
GO:0006869 lipid transport
GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum
GO:0006897 endocytosis
GO:0007033 vacuole organization
GO:0015031 protein transport
GO:0015914 phospholipid transport
GO:0045332 phospholipid translocation
GO:0098629 trans-Golgi network membrane organization
GO:0140331 aminophospholipid translocation
Cellular Component
GO:0000139 Golgi membrane
GO:0005768 endosome
GO:0005770 late endosome
GO:0005794 Golgi apparatus
GO:0005802 trans-Golgi network
GO:0005886 plasma membrane
GO:0010008 endosome membrane
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7rd6, PDBe:7rd6, PDBj:7rd6
PDBsum7rd6
PubMed34645814
UniProtP40527|ATC7_YEAST Phospholipid-transporting ATPase NEO1 (Gene Name=NEO1)

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