Structure of PDB 7rd1 Chain A Binding Site BS02

Receptor Information
>7rd1 Chain A (length=942) Species: 1123958 (Chimpanzee adenovirus Y25) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MATPSMLPQWAYMHIAGQDASEYLSPGLVQFARATDTYFSLGNKFRNPTV
APTHDVTTDRSQRLTLRFVPVDREDNTYSYKVRYTLAVGDNRVLDMASTY
FDIRGVLDRGPSFKPYSGTAYNSLAPKGAPNSSQWEQKKAGNGDTMETHT
FGVAPMGGENITIDGLQIGTDATADQDKPIYADKTFQPEPQVGEENWQET
ESFYGGRALKKDTSMKPCYGSYARPTNVKGGQAKLKVGADGVPTKEFDID
LAFFDTPGGTVNGQDEYKADIVMYTENTYLETPDTHVVYKPGKDDASSEI
NLVQQSMPNRPNYIGFRDNFIGLMYYNSTGNMGVLAGQASQLNAVVDLQD
RNTELSYQLLLDSLGDRTRYFSMWNQAVDSYDPDVRIIENHGVEDELPNY
CFPLDGSGTNAAYQGVKVKNGNDGDVESEWENDDTVAARNQLCKGNIFAM
EINLQANLWRSFLYSNVALYLPDSYKYTPANITLPTNTNTYDYMNGRVVP
PSLVDAYINIGARWSLDPMDNVNPFNHHRNAGLRYRSMLLGNGRYVPFHI
QVPQKFFAIKSLLLLPGSYTYEWNFRKDVNMILQSSLGNDLRTDGASISF
TSINLYATFFPMAHNTASTLEAMLRNDTNDQSFNDYLSAANMLYPIPANA
TNVPISIPSRNWAAFRGWSFTRLKTKETPSLGSGFDPYFVYSGSIPYLDG
TFYLNHTFKKVSITFDSSVSWPGNDRLLTPNEFEIKRTVDGEGYNVAQCN
MTKDWFLVQMLAHYNIGYQGFYVPEGYKDRMYSFFRNFQPMSRQVVDEVN
YKDYQAVTLAYQHNNSGFVGYLAPTMRQGQPYPANYPYPLIGKSAVTSVT
QKKFLCDRVMWRIPFSSNFMSMGALTDLGQNMLYANSAHALDMNFEVDPM
DESTLLYVVFEVFDVVRVHQPHRGVIEAVYLRTPFSAGNATT
Ligand information
>7rd1 Chain W (length=24) Species: 1123958 (Chimpanzee adenovirus Y25) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
DINFSSLAPRHGTRPFMGTWSDIG
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7rd1 ChAdOx1 interacts with CAR and PF4 with implications for thrombosis with thrombocytopenia syndrome.
Resolution3.07 Å
Binding residue
(original residue number in PDB)		D19 E22 N47 P48 T49 V50 P52 N634 Y636
Binding residue
(residue number reindexed from 1)		D19 E22 N47 P48 T49 V50 P52 N634 Y636
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005198 structural molecule activity
Biological Process
GO:0046718 symbiont entry into host cell
GO:0075521 microtubule-dependent intracellular transport of viral material towards nucleus
Cellular Component
GO:0019028 viral capsid
GO:0039623 T=25 icosahedral viral capsid
GO:0042025 host cell nucleus
GO:0043657 host cell

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7rd1, PDBe:7rd1, PDBj:7rd1
PDBsum7rd1
PubMed34851659
UniProtG9G854

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