Structure of PDB 7rb3 Chain A Binding Site BS02

Receptor Information
>7rb3 Chain A (length=145) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RTIRYVRYESELQMPDIMRLITKDLYSIYTYRYFIHNWPQLCFLAMVGEE
CVGAIVCKLDMFRRGYIAMLAVDSKYRRNGIGTNLVKKAIYAMVEGDCDE
VVLETEITNKSALKLYENLGFVRDKRLFRYYLNGVDALRLKLWLR
Ligand information
Ligand IDMET
InChIInChI=1S/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1
InChIKeyFFEARJCKVFRZRR-BYPYZUCNSA-N
SMILES
SoftwareSMILES
CACTVS 3.341CSCC[CH](N)C(O)=O
OpenEye OEToolkits 1.5.0CSCCC(C(=O)O)N
CACTVS 3.341CSCC[C@H](N)C(O)=O
OpenEye OEToolkits 1.5.0CSCC[C@@H](C(=O)O)N
ACDLabs 10.04O=C(O)C(N)CCSC
FormulaC5 H11 N O2 S
NameMETHIONINE
ChEMBLCHEMBL42336
DrugBankDB00134
ZINCZINC000001532529
PDB chain7rb3 Chain A Residue 402 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7rb3 Molecular role of NAA38 in thermostability and catalytic activity of the human NatC N-terminal acetyltransferase.
Resolution3.1 Å
Binding residue
(original residue number in PDB)		E321 Y348
Binding residue
(residue number reindexed from 1)		E104 Y131
Annotation score1
Enzymatic activity
Enzyme Commision number 2.3.1.256: N-terminal methionine N(alpha)-acetyltransferase NatC.
Gene Ontology
Molecular Function
GO:0004596 peptide alpha-N-acetyltransferase activity
GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups
Biological Process
GO:0017196 N-terminal peptidyl-methionine acetylation

View graph for
Molecular Function
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Biological Process
External links
PDB RCSB:7rb3, PDBe:7rb3, PDBj:7rb3
PDBsum7rb3
PubMed36638802
UniProtQ147X3|NAA30_HUMAN N-alpha-acetyltransferase 30 (Gene Name=NAA30)

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