Structure of PDB 7r3x Chain A Binding Site BS02

Receptor Information
>7r3x Chain A (length=1122) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KYNTLSNNYALSAQQLLNASKIDDIDSMMGFERYVPPQYNGRFDAKDIDQ
IPGRVGWLTNMHATLVSQENQGISGVDFYFLDEEGGSFKSTVVYDPYFFI
ACNDESRVNDVEELVKKYLESCLKSLQIIRKEDLTMDNHLLGLQKTLIKL
SFVNSNQLFEARKLLRPILQDNANNNVQRNIYNVKVDAKHLIEDIREYDV
PYHVRVSIDKDIRVGKWYKVTQQGFIEDTRKIAFADPVVMAFDIETTKPP
LKFPDSAVDQIMMISYMIDGEGFLITNREIISEDIEDFEYTPKPEYPGFF
TIFNENDEVALLQRFFEHIRDVRPTVISTFNGDFFDWPFIHNRSKIHGLD
MFDEIGFAPDAEGEYKSSYCSHMDCFRWVKRDSYLPQGSQGVKAVTQSKL
GYNPIELDPELMTPYAFEKPQHLSEYSVSDAVATYYLYMKYVHPFIFSLC
TIIPLNPDETLRKGTGTLCEMLLMVQAYQHNILLPNKHTDPIERFYDGHL
LESETYVGGHVESLEAGVFRSDLKNEFKIDPSAIDELLQELPEALKFSVE
VENKSSVDKVTNFEEIKNQITQKLLELKENNIRNELPLIYHVDVASMYPN
IMTTNRLQPDSIKTCARKLKWAWRGEFFPSKMDEYNMIKRALQNETFPNK
NKFSKKKVLTFDELSYADQVIHIKKRLTEYSRKVYHRVKVSEIVEREAIV
CQRENPFYVDTVKSFRDRRYEFKGLAKTWKGNLSKIDPSDKHARDEAKKM
IVLYDSLQLAHKVILNSFYGYVMRKGSRWYSMEMAGITCLTGATIIQMAR
ALVERVGRPLELDTDGIWCILPKSFPETYFFTLENGKKLYLSYPCSMLNY
RVHQKFTNHQYQELKDPLNYIYETHSENTIFFEVDGPYKAMILPSSKEEG
KGIKKRYAVFNEDGSLAELKGFELKRRGELQLIKNFQSDIFKVFLEGDTL
EGCYSAVASVCNRWLDVLDSHGLMLEDEDLVSLICENRSMSKTLKEYEGQ
KSTSITTARRLGDFLGEDMVKDKGLQCKYIISSKPFNAPVTERAIPVAIF
SADIPIKRSFLRRWTLDPSLEDLDIRTIIDWGYYRERLGSAIQKIITIPA
ALQGVSNPVPRVEHPDWLKRKI
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7r3x Enhanced polymerase activity permits efficient synthesis by cancer-associated DNA polymerase ε variants at low dNTP levels.
Resolution2.46 Å
Binding residue
(original residue number in PDB)		K510 G511 T512 G513 T514 T552 Y553 G555 G556 V558 R686 S829 G832 M835 R836 K837 I965 K966 K967 K1063 T1103 Y1145 K1156
Binding residue
(residue number reindexed from 1)		K463 G464 T465 G466 T467 T505 Y506 G508 G509 V511 R624 S767 G770 M773 R774 K775 I903 K904 K905 K1001 T1041 Y1083 K1094
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
3.1.11.-
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
Biological Process
GO:0006260 DNA replication
GO:0006281 DNA repair
Cellular Component
GO:0008622 epsilon DNA polymerase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7r3x, PDBe:7r3x, PDBj:7r3x
PDBsum7r3x
PubMed35822874
UniProtP21951|DPOE_YEAST DNA polymerase epsilon catalytic subunit A (Gene Name=POL2)

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