Structure of PDB 7r2t Chain A Binding Site BS02

Receptor Information
>7r2t Chain A (length=416) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
YLVTEEEINLTRGPSGLGFNIVGGTDQQYVSNDSGIYVSRIKENGAAALD
GRLQEGDKILSVNGQDLKNLLHQDAVDLFRNAGYAVSLRVQHRLQVQGSA
YGSVKAYTNFDAERDALNIETAIKTKGVDEVTIVNILTNRSNEQRQDIAF
AYQRRTKKELASALKSALSGHLETVILGLLKTPAQYDASELKASMKGLGT
DEDSLIEIICSRTNQELQEINRVYKEMYKTDLEKDIISDTSGDFRKLMVA
LAKGRRAEDGSVIDYELIDQDARDLYDAGVKRKGTDVPKWISIMTERSVP
HLQKVFDRYKSYSPYDMLESIRKEVKGDLENAFLNLVQCIQNKPLYFADR
LYDSMKGKGTRDKVLIRIMVSRSEVDMLKIRSEFKRKYGKSLYYYIQQDT
KGDYQKALLYLCGGDD
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain7r2t Chain A Residue 501 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7r2t SYNJ2BP PDZ domain in complex with a synthetic Vangl2 peptide.
Resolution2.5 Å
Binding residue
(original residue number in PDB)		G133 E136
Binding residue
(residue number reindexed from 1)		G127 E130
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0004859 phospholipase inhibitor activity
GO:0005509 calcium ion binding
GO:0005544 calcium-dependent phospholipid binding
GO:0008092 cytoskeletal protein binding

View graph for
Molecular Function
External links
PDB RCSB:7r2t, PDBe:7r2t, PDBj:7r2t
PDBsum7r2t
PubMed38142947
UniProtP57105|SYJ2B_HUMAN Synaptojanin-2-binding protein (Gene Name=SYNJ2BP)

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