Structure of PDB 7r0e Chain A Binding Site BS02

Receptor Information
>7r0e Chain A (length=709) Species: 1318616 (Influenza A virus (A/Zhejiang/DTID-ZJU01/2013(H7N9))) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GMEDFVRQCFNPMIVELAEKAMKEYGEDPKIETNKFASICTHLEVCFMYS
DFHFIDERGESTIILKHRFEIIEGRDRTMAWTVVNSICNTTGVEKPKFLP
DLYDYKENRFIEIGVTRREVHIYYLEKANKIKSEKTHIHIFSFTGEEMAT
KADYTLDEESRARIKTRLFTIRQEMASRGLWDSFRQSERGEETIEERFEI
TGTMRRLADQSLPPNFSSLENFRAYVDGFEPNGCIEGKLSQMSKEVNARI
EPFLRTTPRPLRLPDGPPCSQRSKFLLMDALKLSIEDPSHEGEGIPLYDA
IKCMKTFFGWKEPNIIKPHEKGINPNYLLTWKQVLAELQDIENEEKIPRT
KNMKKTSQLKWALGENMAPEKVDFEDCKDVNDLKQYDSDEPEPRSLACWI
QSEFNKACELTDSSWVELDEIGEDVAPIEHIASMRRNYFTAEVSHCRATE
YIMKGVYINTALLNASCAAMDDFQLIPMISKCRTKEGRRKTNLYGFIIKG
RSHLRNDTDVVNFVSMEFSLTDPRLEPHKWEKYCVLEIGDMLLRTAVGQV
SRPMFLYVRTNGTSKIKMKWGMEMRRCLLQSLQQIESMIEAESSVKEKDL
TKEFFENKSETWPIGESPKGVEEGSIGKVCRTLLAKSVFNSLYASPQLEG
FSAESRKLLLIVQALRDNLEPGTFDLEGLYEAIEECLINDPWVLLNASWF
NSFLTHALR
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB7r0e Direct observation of backtracking by influenza A and B polymerases upon consecutive incorporation of the nucleoside analog T1106.
Resolution2.51 Å
Binding residue
(original residue number in PDB)		H326 K328 G371 N373 M374 A375 Y393 S395 E397 P398 H510 R512 V517 N519 K539 R566 T567 N568 K574 P653
Binding residue
(residue number reindexed from 1)		H319 K321 G364 N366 M367 A368 Y386 S388 E390 P391 H503 R505 V510 N512 K532 R559 T560 N561 K567 P646
Enzymatic activity
Enzyme Commision number 3.1.-.-
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0004519 endonuclease activity
GO:0046872 metal ion binding
Biological Process
GO:0006351 DNA-templated transcription
GO:0039523 symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity
GO:0039694 viral RNA genome replication
GO:0075523 viral translational frameshifting
GO:0075526 cap snatching
Cellular Component
GO:0030430 host cell cytoplasm
GO:0042025 host cell nucleus

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7r0e, PDBe:7r0e, PDBj:7r0e
PDBsum7r0e
PubMed36596301
UniProtM9TI86

[Back to BioLiP]