Structure of PDB 7qbd Chain A Binding Site BS02

Receptor Information
>7qbd Chain A (length=400) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EMCEIPEMDSHLVEKLGQHLLPWMDRLSLEHLNPSIYVGLRLSSLQAGTK
EDLYLHSLKLGYQQCLLGCQGKPSMGQLALYLLALRANCEFVRGHKGDRL
VSQLKWFLEDEKRAIGHDHKGHPHTSYYQYGLGILALCLHQKRVHDSVVD
KLLYAVEPFHQGHHSVDTAAMAGLAFTCLKRSNFNPGRRQRITMAIRTVQ
EEILKAQTPEGHFGNVYSTPLALQFLMTSPMRGAELGTACLKARVALLAS
LQDGAFQNALMISQLLPVLNHKTYIDLIFPDCLAPRVMLEPAAETIPQTQ
EIISVTLQVLSLLPPYRQSISVLAGSTVEDVLKKAHELGGFTYETQASLS
GPYLTSVMGKAAGEREFWQLLRDPNTPLLQGIADYRPKDGETIELRLVSW
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain7qbd Chain A Residue 502 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7qbd Generation of nanobodies targeting the human, transcobalamin-mediated vitamin B 12 uptake route.
Resolution4.18 Å
Binding residue
(original residue number in PDB)		Y226 Q266 N267 Q389
Binding residue
(residue number reindexed from 1)		Y217 Q257 N258 Q380
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0031419 cobalamin binding
GO:0046872 metal ion binding
GO:0140355 cargo receptor ligand activity
Biological Process
GO:0006824 cobalt ion transport
GO:0015889 cobalamin transport
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005886 plasma membrane
GO:0009897 external side of plasma membrane
GO:0043202 lysosomal lumen

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7qbd, PDBe:7qbd, PDBj:7qbd
PDBsum7qbd
PubMed35218573
UniProtP20062|TCO2_HUMAN Transcobalamin-2 (Gene Name=TCN2)

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