Structure of PDB 7q4o Chain A Binding Site BS02

Receptor Information
>7q4o Chain A (length=836) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ERNRPLSDEELDAMFPEGYKVLEQKERKIMKLLLKIKNGTPPMRKAALRQ
ITDKAREFGAGPLFNQILPLLMSPTLEDQERHLLVKVIDRILYKLDDLVR
PYVHKILVVIEPLLIDEDYYARVEGREIISNLAKAAGLATMISTMRPDID
NMDEYVRNTTARAFAVVASALGIPSLLPFLKAVCKSKKSWQARHTGIKIV
QQIAILMGCAILPHLRSLVEIIEHGLVDEQQKVRTISALAIAALAEAATP
YGIESFDSVLKPLWKGIRQHRGKGLAAFLKAIGYLIPLMDAEYANYYTRE
VMLILIREFQSPDEEMKKIVLKVVKQCCGTDGVEANYIKTEILPPFFKHF
WQHRMALDRRNYRQLVDTTVELANKVGAAEIISRIVDDLKDEAEQYRKMV
METIEKIMGNLGAADIDHKLEEQLIDGILYAFQEQTTEDSVMLNGFGTVV
NALGKRVKPYLPQICGTVLWRLNNKSAKVRQQAADLISRTAVVMKTCQEE
KLMGHLGVVLYEYLGEEYPEVLGSILGALKAIVNVIGMHKMTPPIKDLLP
RLTPILKNRHEKVQENCIDLVGRIADRGAEYVSAREWMRICFELLELLKA
HKKAIRRATVNTFGYIAKAIGPHDVLATLLNNLKVQERQNRVCTTVAIAI
VAETCSPFTVLPALMNEYRVPELNVQNGVLKSLSFLFEYIGEMGKDYIYA
VTPLLEDALMDRDLVHRQTASAVVQHMSLGVYGFGCEDSLNHLLNYVWPN
VFETSPHVIQAVMGALEGLRVAIGPCRMLQYCLQGLFHPARKVRDVYWKI
YNSIYIGSQDALIAHYPRIYNDDKNTYIRYELDYIL
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7q4o Structural basis of branch site recognition by the human spliceosome.
Resolution2.1 Å
Binding residue
(original residue number in PDB)		T508 H1069 K1071 R1075 R1106 Q1107 R1109 V1110 V1114 N1142 K1149 F1153 V1183 Q1186 H1225
Binding residue
(residue number reindexed from 1)		T40 H601 K603 R607 R638 Q639 R641 V642 V646 N674 K681 F685 V715 Q718 H757
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003729 mRNA binding
GO:0005515 protein binding
GO:1990935 splicing factor binding
Biological Process
GO:0000245 spliceosomal complex assembly
GO:0000375 RNA splicing, via transesterification reactions
GO:0000398 mRNA splicing, via spliceosome
GO:0006338 chromatin remodeling
GO:0006397 mRNA processing
GO:0008380 RNA splicing
GO:0045943 positive regulation of transcription by RNA polymerase I
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0045945 positive regulation of transcription by RNA polymerase III
GO:1903241 U2-type prespliceosome assembly
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005681 spliceosomal complex
GO:0005684 U2-type spliceosomal complex
GO:0005686 U2 snRNP
GO:0005689 U12-type spliceosomal complex
GO:0005730 nucleolus
GO:0016607 nuclear speck
GO:0034693 U11/U12 snRNP
GO:0071004 U2-type prespliceosome
GO:0071005 U2-type precatalytic spliceosome
GO:0071013 catalytic step 2 spliceosome
GO:0110016 B-WICH complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7q4o, PDBe:7q4o, PDBj:7q4o
PDBsum7q4o
PubMed34822310
UniProtO75533|SF3B1_HUMAN Splicing factor 3B subunit 1 (Gene Name=SF3B1)

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