Structure of PDB 7pvn Chain A Binding Site BS02

Receptor Information
>7pvn Chain A (length=998) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ASVEIDDALYSRQRYVLGDTAMQKMAKSHVFLSGMGGLGLEIAKNLVLAG
IKAVTIHDTEKCQAWDLGTNFFLSEDDVVNKRNRAEAVLKHIAELNPYVH
VTSSSVPFNETTDLSFLDKYQCVVLTEMKLPLQKKINDFCRSQCPPIKFI
SADVHGIWSRLFCDFGDEFEVLDTTGEEPKEIFISNITQANPGIVTCLEN
HPHKLETGQFLTFREINGMTGLNGSIQQITVISPFSFSIGDTTELEPYLH
GGIAVQVKTPKTVFFESLERQLKHPKCLIVDFSNPEAPLEIHTAMLALDQ
FQEKYSRKPNVGCQQDSEELLKLATSISETLEEKPDVNADIVHWLSWTAQ
GFLSPLAAAVGGVASQEVLKAVTGKFSPLCQWLYLEAADIVESLGKPECE
EFLPRGDRYDALRACIGDTLCQKLQNLNIFLVGCGAIGCEMLKNFALLGV
GTSKEKGMITVTDPDLIEKSNLNRQFLFRPHHIQKPKSYTAADATLKINS
QIKIDAHLNKVCPTTETIYNDEFYTKQDVIITALDNVEARRYVDSRCLAN
LRPLLDSGTMGTKGHTEVIVPHLTESYNSHRDPPEEEIPFATLKSFPAAI
EHTIQWARDKFESSFSHKPSLFNKFWQTYSSAEEVLQKIQSGHSLEGCFQ
VIKLLSRRPRNWSQCVELARLKFEKYFNHKALQLLHCFPLDIRLKDGSLF
WQSPKRPPSPIKFDLNEPLHLSFLQNAAKLYATVYCIPFAEEDLSADALL
NILSEVKIQEFKPSNKVSEDERNAIFQLEKAILSNEATKSDLQMAVLSFE
KDDDHNGHIDFITAASNLRAKMYSIEPADRFKTKRIAGKIIPAIATTTAT
VSGLVALEMIKVTGGYPFEAYKNCFLNLAIPIVVFTETTEVRKTKIRNGI
SFTIWDRWTVHGKEDFTLLDFINAVKEKYGIEPTMVVQGVKMLYVPVMPG
HAKRLKLTMHKLVKPTTEKKYVDLTVSFAPDDEDLPGPPVRYYFSHDT
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain7pvn Chain A Residue 1108 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7pvn Structures of UBA6 explain its dual specificity for ubiquitin and FAT10.
Resolution2.71 Å
Binding residue
(original residue number in PDB)		D499 E502
Binding residue
(residue number reindexed from 1)		D465 E468
Annotation score1
Enzymatic activity
Enzyme Commision number 6.2.1.45: E1 ubiquitin-activating enzyme.
Gene Ontology
Molecular Function
GO:0004792 thiosulfate sulfurtransferase activity
GO:0004839 ubiquitin activating enzyme activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008641 ubiquitin-like modifier activating enzyme activity
GO:0016779 nucleotidyltransferase activity
GO:0016874 ligase activity
GO:0019780 FAT10 activating enzyme activity
Biological Process
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0007612 learning
GO:0007626 locomotory behavior
GO:0016567 protein ubiquitination
GO:0021764 amygdala development
GO:0021766 hippocampus development
GO:0032446 protein modification by small protein conjugation
GO:0036211 protein modification process
GO:0060996 dendritic spine development
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

View graph for
Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7pvn, PDBe:7pvn, PDBj:7pvn
PDBsum7pvn
PubMed35970836
UniProtA0AVT1|UBA6_HUMAN Ubiquitin-like modifier-activating enzyme 6 (Gene Name=UBA6)

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