Structure of PDB 7pfa Chain A Binding Site BS02

Receptor Information
>7pfa Chain A (length=97) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KPHRYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQS
SAVMALQEASEAYLVGLFEDTNLAAIHAKRVTIMPKDIQLARRIRGE
Ligand information
>7pfa Chain J (length=561) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
tacttacatgacaggatgtatatatctgacacgtgcctggagactaggga
gtaatccccttggcggttaaaacgcgggggacagcgcgtacgtgcgttta
agcggtgctagagctgtctacgaccaattgagcggcctcggcaccgggat
tctccagtatggcggccagtgcgcgagacagtactgggttaccttaatac
ttacatgacaggatgtatatatctgacacgtgcctggagactagggagta
atccccttggcggttaaaacgcgggggacagcgcgtacgtgcgtttaagc
ggtgctagagctgtctacgaccaattgagcggcctcggcaccgggattct
ccagtatggcggccagtgcgcgagacagtactgggttaccttaatactta
catgacaggatgtatatatctgacacgtgcctggagactagggagtaatc
cccttggcggttaaaacgcgggggacagcgcgtacgtgcgtttaagcggt
gctagagctgtctacgaccaattgagcggcctcggcaccgggattctcca
gtatggcggcc
Receptor-Ligand Complex Structure
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PDB7pfa Histone H1 binding to nucleosome arrays depends on linker DNA length and trajectory.
Resolution9.7 Å
Binding residue
(original residue number in PDB)		R40 Y41 P43 G44 V46 A47 R52 K56 R63 K64 L65 R69 R83 K115
Binding residue
(residue number reindexed from 1)		R4 Y5 P7 G8 V10 A11 R16 K20 R27 K28 L29 R33 R47 K79
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0030527 structural constituent of chromatin
GO:0046982 protein heterodimerization activity
Biological Process
GO:0006325 chromatin organization
GO:0006334 nucleosome assembly
Cellular Component
GO:0000786 nucleosome
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005694 chromosome
GO:0070062 extracellular exosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7pfa, PDBe:7pfa, PDBj:7pfa
PDBsum7pfa
PubMed35581345
UniProtQ71DI3|H32_HUMAN Histone H3.2 (Gene Name=H3C15)

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