Structure of PDB 7p7p Chain A Binding Site BS02

Receptor Information
>7p7p Chain A (length=911) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PGAFPVATNGERFPWQELRLPSVVIPLHYDLFVHPNLTSLDFVASEKIEV
LVSNATQFIILHSKDLEITNATLQSEEDSRYMKPGKELKVLSYPAHEQIA
LLVPEKLTPHLKYYVAMDFQAKLGDGFEGFYKSTYRTLGGETRILAVTDF
EPTQARMAFPCFDEPLFKANFSIKIRRESRHIALSNMPKVKTIELEGGLL
EDHFETTVKMSTYLVAYIVCDFHSLSGFTSSGVKVSIYASPDKRNQTHYA
LQASLKLLDFYEKYFDIYYPLSKLDLIAIPDFAPGAMENWGLITYRETSL
LFDPKTSSASDKLWVTRVIAHELAHQWFGNLVTMEWWNDIWLNEGFAKYM
ELIAVNATYPELQFDDYFLNVCFEVITKDSLNSSRPISKPAETPTQIQEM
FDEVSYNKGACILNMLKDFLGEEKFQKGIIQYLKKFSYRNAKNDDLWSSL
SNSCLESDFTSGGVCHSDKMTSNMLAFLGENAEVKEMMTTWTLQKGIPLL
VVKQDGCLRLQQERFLQGVFQEDPEWRALQERYLWHIPLTYSTSSSNVIH
RHILKSKTDTLDLPEKTSWVKFNVDSNGYYIVHYEGHGWDQLITQLNQNH
TLLRPKDRVGLIHDVFQLVGAGRLTLDKALDMTYYLQHETSSPALLEGLS
YLESFYHMMDRRNISDISENLKRYLLQYFKPVIDRQSWSDKGSVWDRMLR
SALLKLACDLNHAPCIQKAAELFSQWMESSGKLNIPTDVLKIVYSVGAQT
TAGWNYLLEQYELSMSSAEQNKILYALSTSKHQEKLLKLIELGMEGKVIK
TQNLAALLHAIARRPKGQQLAWDFVRENWTHLLKKFDLGSYDIRMIISGT
TAHFSSKDKLQEVKLFFESLEAQGSHLDIFQTVLETITKNIKWLEKNLPT
LRTWLMVNTRH
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain7p7p Chain A Residue 1119 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB7p7p Inhibitor-Dependent Usage of the S1' Specificity Pocket of ER Aminopeptidase 2.
Resolution3.0 Å
Binding residue
(original residue number in PDB)		H370 H374 E393
Binding residue
(residue number reindexed from 1)		H321 H325 E344
Annotation score4
Enzymatic activity
Enzyme Commision number 3.4.11.-
Gene Ontology
Molecular Function
GO:0004175 endopeptidase activity
GO:0004177 aminopeptidase activity
GO:0005515 protein binding
GO:0008237 metallopeptidase activity
GO:0008270 zinc ion binding
GO:0042277 peptide binding
GO:0046872 metal ion binding
GO:0070006 metalloaminopeptidase activity
Biological Process
GO:0002250 adaptive immune response
GO:0002474 antigen processing and presentation of peptide antigen via MHC class I
GO:0006508 proteolysis
GO:0008217 regulation of blood pressure
GO:0019885 antigen processing and presentation of endogenous peptide antigen via MHC class I
GO:0043171 peptide catabolic process
Cellular Component
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005788 endoplasmic reticulum lumen
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7p7p, PDBe:7p7p, PDBj:7p7p
PDBsum7p7p
PubMed35178178
UniProtQ6P179|ERAP2_HUMAN Endoplasmic reticulum aminopeptidase 2 (Gene Name=ERAP2)

[Back to BioLiP]