Structure of PDB 7oyx Chain A Binding Site BS02

Receptor Information
>7oyx Chain A (length=347) Species: 83333 (Escherichia coli K-12) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QKTLHIYNWTDYIAPDTVANFEKETGIKVVYDVFDSNEVLEGKLMAGSTG
FDLVVPSASYLERQLTAGVFQPLDKSKLPEWKNLDPELLKLVAKHDPDNK
FAMPYMWATTGIGYNVDKVKAVLGENAPVDSWDLILKPENLEKLKSCGVS
FLDDPEEVFATVLNYLGKDPNSTKADDYTGPATDLLLKLRPNIRYFHSSQ
YINDLANGDICVAIGWAGDVWQASNRAKEAKNGVNVSFSIPKEGAMAWFD
VFAMPADAKNKDEAYQFLNYLLRPDVVAHISDHVFYANANKAATPLVSAE
VRENPGIYPPADVRAKLFTQKVQDPKIDRVRTRAWTKVKSGKLEHHH
Ligand information
Ligand ID3IE
InChIInChI=1S/C4H11NO/c1-4(5)3-6-2/h4H,3,5H2,1-2H3/t4-/m0/s1
InChIKeyNXMXETCTWNXSFG-BYPYZUCNSA-N
SMILES
SoftwareSMILES
CACTVS 3.385COC[C@H](C)N
OpenEye OEToolkits 2.0.7CC(COC)N
CACTVS 3.385COC[CH](C)N
OpenEye OEToolkits 2.0.7C[C@@H](COC)N
FormulaC4 H11 N O
Name(2~{S})-1-methoxypropan-2-amine
ChEMBL
DrugBank
ZINCZINC000002572631
PDB chain7oyx Chain A Residue 402 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7oyx Fine-tuning spermidine binding modes in the putrescine binding protein PotF.
Resolution1.37 Å
Binding residue
(original residue number in PDB)		K30 K287 N288
Binding residue
(residue number reindexed from 1)		K2 K259 N260
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0019808 polyamine binding
GO:0019810 putrescine binding
Biological Process
GO:0015846 polyamine transport
GO:0015847 putrescine transport
Cellular Component
GO:0016020 membrane
GO:0030288 outer membrane-bounded periplasmic space
GO:0042597 periplasmic space
GO:0055052 ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7oyx, PDBe:7oyx, PDBj:7oyx
PDBsum7oyx
PubMed34801550
UniProtP31133|POTF_ECOLI Putrescine-binding periplasmic protein PotF (Gene Name=potF)

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