Structure of PDB 7oyv Chain A Binding Site BS02

Receptor Information

>7oyv Chain A (length=341) Species: 562 (Escherichia coli)

QKTLHIYNWTDYIAPDTVANFEKETGIKVVYDVFDSNEVLEGKLMAGSTG
FDLVVPSAYALERQLTAGVFQPLDKSKLPEWKNLDPELLKLVAKHDPDNK
FAMPYMWATTGIGYNVDKVKAVLGENAPVDSWDLILKPENLEKLKSCGVS
FLDDPEEVFATVLNYLGKDPNSTKADDYTGPATDLLLKLRPNIRYFHSSQ
YINDLANGDICVAIGWAGDVWQASNRAKEAKNGVNVSFSIPKEGAMAWFD
VFAMPADAKNKDEAYQFLNYLLRPDVVAHISDHVFYANANKAATPLVSAE
VRENPGIYPPADVRAKLFTQKVQDPKIDRVRTRAWTKVKSG

Ligand information

• Ligand ID: JFN
• InChI: InChI=1S/C4H11NO/c1-4(5)3-6-2/h4H,3,5H2,1-2H3/t4-/m1/s1
• InChIKey: NXMXETCTWNXSFG-SCSAIBSYSA-N
• SMILES:
  OpenEye OEToolkits 2.0.6: CC(COC)N
  CACTVS 3.385: COC[C@@H](C)N
  CACTVS 3.385: COC[CH](C)N
  OpenEye OEToolkits 2.0.6: C[C@H](COC)N
  ACDLabs 12.01: COCC(C)N
• Formula: C4 H11 N O
• Name: (2R)-1-methoxypropan-2-amine;
  jeffamine
• ZINC: ZINC000004862149
• PDB chain: 7oyv Chain A Residue 502

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7oyv Fine-tuning spermidine binding modes in the putrescine binding protein PotF.
• Resolution: 1.9 Å
• Binding residue (original residue number in PDB): P338 A339 R342
• Binding residue (residue number reindexed from 1): P310 A311 R314
• Annotation score: 1

Gene Ontology

Molecular Function

• GO:0019808 polyamine binding
• GO:0019810 putrescine binding

Biological Process

• GO:0015846 polyamine transport
• GO:0015847 putrescine transport

Cellular Component

• GO:0016020 membrane
• GO:0030288 outer membrane-bounded periplasmic space
• GO:0042597 periplasmic space
• GO:0055052 ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing

External links

• PDB: RCSB:7oyv, PDBe:7oyv, PDBj:7oyv
• PDBsum: 7oyv
• PubMed: 34801550
• UniProt: P31133|POTF_ECOLI Putrescine-binding periplasmic protein PotF (Gene Name=potF)