Structure of PDB 7ovs Chain A Binding Site BS02

Receptor Information
>7ovs Chain A (length=382) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PKLSLIKVVNGCRLGKIQNLGKAGDCTVDIPGCLLYTRTGSAPHLTHQTL
RNIHGVPGIAQLTLSSLAEHHEVLAEYKKGVGSFIGMPESLFYCSLHDPV
TPGPAGYVTSKSVSVWGFGGRVEMTVSKFMAIQEALQPDWFQCLSDGEAS
CAETTSIKRARKSVDRSLLFLDSCLRLQEESEVLQKSVIIGVIEGGDVME
ERLRSARETAKRPVGGFLLDGFQGDPAVTETRLHLLSSVTAELPEDKPRL
ICGVSRPDEVLECIERGVDLFESFFPYQVTERGCALTFTFDCQLEMTSFE
INLKEKKYQEDFDPLVRGCSCYCCKNHTRAYIHHLLMTNELLAGVLLMMH
NFEHYFGFFCSIREALKNDTLAQLKELICRQM
Ligand information
Ligand IDTEW
InChIInChI=1S/O6Te.H2O.17O.6W/c1-7(2,3,4,5)6;;;;;;;;;;;;;;;;;;;;;;;;/h;1H2;;;;;;;;;;;;;;;;;;;;;;;/q;;;;;;;;;;;;;6*-1;;;;;;+1/p-1
InChIKeyJDLYBIMRCSJRQJ-UHFFFAOYSA-M
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.7.6[O-]=[W]123(O[W]45(=O)(O1[Te]6789O2[W]1(=O)(O3)(O6[W]2(=O)(O1)(O7[W]1(=O)(O2)(O8[W](=O)(O94)(O5)(O1)[O-])[O-])[O-])[O-])[O-])[O]
FormulaO24 Te W6
Name6-tungstotellurate(VI)
ChEMBL
DrugBank
ZINC
PDB chain7ovs Chain A Residue 502 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7ovs Structural and Biochemical Investigation of the Heterodimeric Murine tRNA-Guanine Transglycosylase.
Resolution2.6 Å
Binding residue
(original residue number in PDB)		T109 S110 K111 K162 R166
Binding residue
(residue number reindexed from 1)		T109 S110 K111 K162 R166
Annotation score1
Enzymatic activity
Enzyme Commision number 2.4.2.29: tRNA-guanosine(34) preQ1 transglycosylase.
Gene Ontology
Molecular Function
GO:0000049 tRNA binding
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0008479 tRNA-guanosine(34) queuine transglycosylase activity
GO:0016763 pentosyltransferase activity
GO:0042803 protein homodimerization activity
GO:0046872 metal ion binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0006400 tRNA modification
GO:0008033 tRNA processing
GO:0101030 tRNA-guanine transglycosylation
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005741 mitochondrial outer membrane
GO:0032473 cytoplasmic side of mitochondrial outer membrane
GO:0032991 protein-containing complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7ovs, PDBe:7ovs, PDBj:7ovs
PDBsum7ovs
PubMed35815944
UniProtB8ZXI1|QTRT2_MOUSE Queuine tRNA-ribosyltransferase accessory subunit 2 (Gene Name=Qtrt2)

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