Structure of PDB 7orn Chain A Binding Site BS02

Receptor Information
>7orn Chain A (length=1700) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MDYQEYQQFLARINTARDACVAKDIDVDLLMARKDYFGRELCKSLNIEYR
NDVPFIDIILDIRPEVDPLTIDAPHITPDNYLYINNVLYIIDYKVSVSNE
SSVITYDKYYELTRDISDRLSIPIEIVIIRIDPVSRDLHINSDRFKELYP
TIVVDINFNQFFDLKQLLYEKFGDDEEFLLKVAHGDFTLTAPWCKTGCPE
FWKHPIYKEFKMSMPVPERRLFEESVKFNAYESERWNTNLVKIREYTKKD
YSEHISKSAKNIFLASGFYKQPNKNEISEGWTLMVERVQDQREISKSLHD
QKPSIHFIWGAHNPGNSNNATFKLILLSKSLQSIKGISTYTEAFKSLGKM
MDIGDKAIEYEEFCMSLKSKLEPKQINNALVLWEQQFMINNDLIDKSEKL
KLFKNFCGIGKHKQFKNKMLEDLEVSKPKILDFDDANMYLASLTMMEQSK
KILSKSNGLKPDNFILNEFGSRIKDANKETYDNMHKIFETGYWQCISDFS
TLMKNILSVSQYNRHNTFRIAMCANNNVFAIVFPSADIKTKKATVVYSII
VLHKEEENIFNPGCLHGTFKCMNGYISISRAIRLDKERCQRIVSSPGLFL
TTCLLFKHDNPTLVMSDIMNFSIYTSLSITKSVLSLTEPARYMIMNSLAI
SSNVKDYIAEKFSPYTKTLFSVYMTRLIKNACFDAYDQRQRVQLRDIYLS
DYDITQKGIKDNRELTSIWFPGSVTLKEYLTQIYLPFYFNAKGLHEKHHV
MVDLAKTILEIECEQRENIKEIWSTNCTKQTVNLKILIHSLCKNLLADTS
RHNHLRNRIENRNNFRRSITTISTFTSSKSCLKIGDFRKEKELRKMRLAN
PMFVTDEQVCLEVGHCNYEMLRNAMPNYTDYISTKVFDRLYELLDKKVLT
DKPVIEQIMDMMIDHKKFYFTFFNKGQKTSKDREIFVGEYEAKMCMYAVE
RIAKERCKLNPDEMISEPGDGKLKVLEQKSEQEIRFLVETTRQKNREIGK
AKGLKMEINADMSKWSAQDVFYKYFWLIALDPILYPQEKERILYFMCNYM
DKELILPDELLFNLLDQKVAYQNDIIATMTNQLNSNTVLIKRNWLQGNFN
YTSSYVHSCAMSVYKEILKEAITLLDGSILVNSLVHSDDNQTSITIVQDK
MENDKIIDFAMKEFERACLTFGCQANMKKTYVTNCIKEFVSLFNLYGEPF
SIYGRFLLTSVGDCAYIGPYEDLASRISSAQTAIKHGCPPSLAWVSIAIS
HWMTSLTYNMLPGQSNDPIDYFPAENRKDIPIELNGVLDAPLSMISTVGL
ESGNLYFLIKLLSKYTPVMQKRESVVNQIAEVKNWKVEDLTDNEIFRLKI
LRYLVLDAEMDPSDIMGETSDMRGRSILTPRKFTTAGSLRKLYSFSKYQD
RLSSPGGMVELFTYLLEKPELLVTKGEDMKDYMESVIFRYNSKRFKESLS
IQNPAQLFIEQILFSHKPVIDFSGIRDKKEPDILGKVTFTEAYRLLMRDL
SSLELTNDDIQVIYSYIILNDPMMITIANTHILSIYGSPQRRMGMSCSTM
PEFRNLKLIHHSPALVLRAYSKNNPDIQGADPTEMARDLVHLKEFVENTN
LEEKMKVRIAMNEAEKGQRDIVFELKEMTRFYQVCYEYVKSTEHKIKVFI
LPAKSYTTTDFCSLMQGNLIKDKEWYTVHYLKQILEGEAIHSTPIFNIYY
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB7orn Structural snapshots of La Crosse virus polymerase reveal the mechanisms underlying Peribunyaviridae replication and transcription.
Resolution2.8 Å
Binding residue
(original residue number in PDB)
K416 D549 K551 T552 K553 K554 K598 K759 K841 S842 F948 K950 I960 V962 K968 R976 K979 M989 I990 S991 G1146 N1149 Y1150 F1432 T1434 I1500 N1502 P1503 Q1505 E1509 K1516 D1542
Binding residue
(residue number reindexed from 1)
K404 D537 K539 T540 K541 K542 K586 K747 K829 S830 F923 K925 I935 V937 K943 R951 K954 M964 I965 S966 G1097 N1100 Y1101 F1383 T1385 I1451 N1453 P1454 Q1456 E1460 K1467 D1482
Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.1.-.-
Gene Ontology
Molecular Function
GO:0003968 RNA-dependent RNA polymerase activity
Biological Process
GO:0006351 DNA-templated transcription
GO:0019079 viral genome replication
GO:0039694 viral RNA genome replication

View graph for
Molecular Function

View graph for
Biological Process
External links
PDB RCSB:7orn, PDBe:7orn, PDBj:7orn
PDBsum7orn
PubMed35173159
UniProtA5HC98|L_BUNLC RNA-directed RNA polymerase L (Gene Name=L)

[Back to BioLiP]