Structure of PDB 7orm Chain A Binding Site BS02

Receptor Information
>7orm Chain A (length=2145) Species: 11577 (La Crosse virus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MDYQEYQQFLARINTARDACVAKDIDVDLLMARKDYFGRELCKSLNIEYR
NDVPFIDIILDIRPEVDPLTIDAPHITPDNYLYINNVLYIIDYKVSVSNE
SSVITYDKYYELTRDISDRLSIPIEIVIIRIDPVSRDLHINSDRFKELYP
TIVVDINFNQFFDLKQLLYEKFGDDEEFLLKVAHGDFTLTAPWCKTGCPE
FWKHPIYKEFKMSMPVPERRLFEESVKFNAYESERWNTNLVKIREYTKKD
YSEHISKSAKNIFLASGFYKQPNKNEISEGWTLMVERVQDQREISKSLHD
QKPSIHFIWGAHNPGNSNNATFKLILLSKSLQSIKGISTYTEAFKSLGKM
MDIGDKAIEYEEFCMSLKSKARSSWKQIMNKKLEPKQINNALVLWEQQFM
INNDLIDKSEKLKLFKNFCGIGKHKQEVSKPKILDFDDANMYLASLTMME
QSKKILSKSNGLKPDNFILNEFGSRIKDANKETYDNMHKIFETGYWQCIS
DFSTLMKNILSVSQYNRHNTFRIAMCANNNVFAIVFPSADIKTKKATVVY
SIIVLHKEEENIFNPGCLHGTFKCMNGYISISRAIRLDKERCQRIVSSPG
LFLTTCLLFKHDNPTLVMSDIMNFSIYTSLSITKSVLSLTEPARYMIMNS
LAISSNVKDYIAEKFSPYTKTLFSVYMTRLIKNACFDAYDQRQRVQLRDI
YLSDYDITQKGIKDNRELTSIWFPGSVTLKEYLTQIYLPFYFNAKGLHEK
HHVMVDLAKTILEIECEQRENIKEIWSTNCTKQTVNLKILIHSLCKNLLA
DTSRHNHLRNRIENRNNFRRSITTISTFTSSKSCLKIGDFRKEKENYEML
RNAMPNYTDYISTKVFDRLYELLDKKVLTDKPVIEQIMDMMIDHKKFYFT
FFNKGQKTSKDREIFVGEYEAKMCMYAVERIAKERCKLNPDEMISEPGDG
KLKVLEQKSEQEIRFLVETTRQKNREIDEAIEIEKLSLGKAKGLKMEINA
DMSKWSAQDVFYKYFWLIALDPILYPQEKERILYFMCNYMDKELILPDEL
LFNLLDQKVAYQNDIIATMTNQLNSNTVLIKRNWLQGNFNYTSSYVHSCA
MSVYKEILKEAITLLDGSILVNSLVHSDDNQTSITIVQDKMENDKIIDFA
MKEFERACLTFGCQANMKKTYVTNCIKEFVSLFNLYGEPFSIYGRFLLTS
VGDCAYIGPYEDLASRISSAQTAIKHGCPPSLAWVSIAISHWMTSLTYNM
LPGQSNDPIDYFPAENRKDIPIELNGVLDAPLSMISTVGLESGNLYFLIK
LLSKYTPVMQKRESVVNQIAEVKNWKVEDLTDNEIFRLKILRYLVLDAEM
DPSDIMGETSDMRGRSILTPRKFTTAGSLRKLYSFSKYQDRLSSPGGMVE
LFTYLLEKPELLVTKGEDMKDYMESVIFRYNSKRFKESLSIQNPAQLFIE
QILFSHKPVIDFSGIRDKYINLGKVTFTEAYRLLMRDLSSLELTNDDIQV
IYSYIILNDPMMITIANTHILSIYGSPQRRMGMSCSTMPEFRNLKLIHHS
PALVLRAYSKNNPDIQGADPTEMARDLVHLKEFVENTNLEEKMKVRIAMN
EAEKGQRDIVFELKEMTRFYQVCYEYVKSTEHKIKVFILPAKSYTTTDFC
SLMQGNLIKDKEWYTVHYLKQILSGGHKAIMQHNATSEQNIAFECFKLIT
HFADSFIDSLSRSAFLQLIIDEFSYKDVKVSKLYDIIKNGYNRTDFIPLL
FRTGDLRQADLDKYDAMKSHERVTLTITGYNRSITIIGEDNKLTYAELCL
TRKTPENITISGRKLLGSRHGLKFENMSKIQNYYITYRKKDRHQFVYQIH
SHESITRRNEEHNEITPVCVVNVAEVDGDQRILIRSLDYLNNDIFSLSRI
KVGLDEFATIKKAHFSKMVSFEGPPIKTGLLDLTELMKSQDLLNLNYDNI
RNSNLISFSKLICCEGSDNINDGLEFLSDDPMNFTEGEAIHSTPIFNIYY
SKRGERHMTYRNAIKLLIERETKIFEEAFTFSENGFISPENLGCLEAVVS
LIKLLKTNEWSTVIDKCIHICLIKNGMDHMYHSFDVPKCFMGNPITRDIN
WVMFREFINSLPGTDIPPWNVMTENFKKKCIALINSKFSEFTKLM
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7orm Structural snapshots of La Crosse virus polymerase reveal the mechanisms underlying Peribunyaviridae replication and transcription.
Resolution3.3 Å
Binding residue
(original residue number in PDB)		S842 F948 K950 I960 F961 V962 R976 K979 P993 G994 Q1145 G1146 Y1150 Y1269 S1277 S1425 R1493 K1705 I1706 K1707
Binding residue
(residue number reindexed from 1)		S833 F902 K904 I914 F915 V916 R930 K933 P947 G948 Q1086 G1087 Y1091 Y1210 S1218 S1366 R1434 K1633 I1634 K1635
Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.1.-.-
Gene Ontology
Molecular Function
GO:0003968 RNA-dependent RNA polymerase activity
Biological Process
GO:0006351 DNA-templated transcription
GO:0019079 viral genome replication
GO:0039694 viral RNA genome replication

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Molecular Function
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Biological Process
External links
PDB RCSB:7orm, PDBe:7orm, PDBj:7orm
PDBsum7orm
PubMed35173159
UniProtA5HC98|L_BUNLC RNA-directed RNA polymerase L (Gene Name=L)

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