Structure of PDB 7okx Chain A Binding Site BS02

Receptor Information
>7okx Chain A (length=1407) Species: 9823 (Sus scrofa) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DSACPLRTIKRVQFGVLSPDELKRMSVTEGGIKYPETTEGGRPKLGGLMD
PRQGVIERTGRCQTCAGNMTECPGHFGHIELAKPVFHVGFLVKTMKVLRC
VCFFCSKLLVDSNNPKIKDILAKSKGQPKKRLTHVYDLCKGKNICEGGGC
GRYQPRIRRSGLELYAEWKHVQEKKILLSPERVHEIFKRISDEECFVLGM
EPRYARPEWMIVTVLPVPPLSVRPAVVMQGSARNQDDLTHKLADIVKINN
QLRRNEQNGAAAHVIAEDVKLLQFHVATMVDNELPGLPRAMQKSGRPLKS
LKQRLKGKEGRVRGNLMGKRVDFSARTVITPDPNLSIDQVGVPRSIAANM
TFAEIVTPFNIDRLQELVRRGNSQYPGAKYIIRDNGDRIDLRFHPKPSDL
HLQTGYKVERHMCDGDIVIFNRQPTLHKMSMMGHRVRILPWSTFRLNLSV
TTPYNADFDGDEMNLHLPQSLETRAEIQELAMVPRMIVTPQSNRPVMGIV
QDTLTAVRKFTKRDVFLERGEVMNLLMFLSTWDGKVPQPAILKPRPLWTG
KQIFSLIIPGHINCIRTHSTHPDDEDSGPYKHISPGDTKVVVENGELIMG
ILCKKSLGTSAGSLVHISYLEMGHDITRLFYSNIQTVINNWLLIEGHTIG
IGDSIADSKTYQDIQNTIKKAKQDVIEVIEKAHNNELEPTPGNTLRQTFE
NQVNRILNDARDKTGSSAQKSLSEYNNFKSMVVSGAKGSKINISQVIAVV
GQQNVEGKRIPFGFKHRTLPHFIKDDYGPESRGFVENSYLAGLTPTEFFF
HAMGGREGLIDTAVKTAETGYIQRRLIKSMESVMVKYDATVRNSINQVVQ
LRYGEDGLAGESVEFQNLATLKPSNKAFEKKFRFDYTNERALRRTLQEDL
VKDVLSNAHIQNELEREFERMREDREVLRVIFPTGDSKVVLPCNLLRMIW
NAQKIFHINPRLPSDLHPIKVVEGVKELSKKLVIVNGDDPLSRQAQENAT
LLFNIHLRSTLCSRRMAEEFRLSGEAFDWLLGEIESKFNQAIAHPGEMVG
ALAAQSLGEPATQMKNVTLGVPRLKELINISKKPKTPSLTVFLLGQSARD
AERAKDILCRLEHTTLRKVTANTAIYYDPNPQSTVVAEDQEWVNVYYISP
WLLRVELDRKHMTDRKLTMEQIAEKINAGFGDDLNCIFNKLVLRIRIMNK
MDDDVFLRCIESNMLTDMTLQGIEQISKVYMHLPQTDNKKKIIITEDGEF
KALQEWILETDGVSLMRVLSEKDVDPVRTTSNDIVEIFTVLGIEAVRKAL
ERELYHVISFDGSYVNYRHLALLCDTMTCRGHLMAITRHGVNRQDTGPLM
KCSFEETVDVLMEAAAHGESDPMKGVSENIMLGQLAPAGTGCFDLLLDAE
KCKYGME
Ligand information
Receptor-Ligand Complex Structure
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PDB7okx Allosteric transcription stimulation by RNA polymerase II super elongation complex.
Resolution3.3 Å
Binding residue
(original residue number in PDB)		N272 P323 Q330 K346 R358 Q461 T854 A855 Y859 R1416 E1433 E1434
Binding residue
(residue number reindexed from 1)		N234 P285 Q292 K308 R320 Q423 T816 A817 Y821 R1338 E1355 E1356
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0016779 nucleotidyltransferase activity
GO:0046872 metal ion binding
Biological Process
GO:0006351 DNA-templated transcription
GO:0006366 transcription by RNA polymerase II
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex
GO:0005634 nucleus
GO:0031981 nuclear lumen
GO:0032991 protein-containing complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7okx, PDBe:7okx, PDBj:7okx
PDBsum7okx
PubMed34265249
UniProtA0A7M4DUC2

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