Structure of PDB 7o5z Chain A Binding Site BS02

Receptor Information
>7o5z Chain A (length=242) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GPALCLFDVDGTLTAPRQKITKEMDDFLQKLRQKIKIGVVGGSDFEKVQE
QLGNDVVEKYDYVFPENGLVAYKDGKLLCRQNIQSHLGEALIQDLINYCL
SYIAKIKLPKKRGTFIEFRNGMLNVSPIGRSCSQEERIEFYELDKKENIR
QKFVADLRKEFAGKGLTFSIGGQISFDVFPDGWDKRYCLRHVENDGYKTI
YFFGDKTMPGGNDHEIFTDPRTMGYSVTAPEDMRRICELLFS
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain7o5z Chain A Residue 306 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7o5z Insight on molecular pathogenesis and pharmacochaperoning potential in phosphomannomutase 2 deficiency, provided by novel human phosphomannomutase 2 structures.
Resolution2.07 Å
Binding residue
(original residue number in PDB)		F221 D223 T226
Binding residue
(residue number reindexed from 1)		F217 D219 T222
Annotation score1
Enzymatic activity
Enzyme Commision number 5.4.2.8: phosphomannomutase.
Gene Ontology
Molecular Function
GO:0004615 phosphomannomutase activity
GO:0005515 protein binding
GO:0016853 isomerase activity
GO:0046872 metal ion binding
Biological Process
GO:0006013 mannose metabolic process
GO:0006486 protein glycosylation
GO:0006487 protein N-linked glycosylation
GO:0009298 GDP-mannose biosynthetic process
GO:0019309 mannose catabolic process
GO:0061728 GDP-mannose biosynthetic process from mannose
GO:0061729 GDP-mannose biosynthetic process from fructose-6-phosphate
GO:0141199 GDP-mannose biosynthetic process from glucose
Cellular Component
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0043025 neuronal cell body

View graph for
Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7o5z, PDBe:7o5z, PDBj:7o5z
PDBsum7o5z
PubMed34859900
UniProtO15305|PMM2_HUMAN Phosphomannomutase 2 (Gene Name=PMM2)

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