Structure of PDB 7nxe Chain A Binding Site BS02
Receptor Information
>7nxe Chain A (length=219) Species:
9606
(Homo sapiens) [
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HSNEKWFHGKLGGRDGRHIAERLLTEYCIETGAPDGSFLVRESETFVGDY
TLSFWRNGKVQHCRIHSRPKFFLTDNLVFDSLYDLITHYQQVPLRCNFEM
RLSEPVPQTNAHESKEWYHASLTRAQAEHMLMRVPRDGAFLVRKRNEPNS
YAISFRAEGKIKHCRVQQEGQTVMLGNSEFDSLVDLISYYEKHPLYRKMK
LRYPINEEALEKIGTAEPD
Ligand information
>7nxe Chain D (length=2) Species:
868565
(Human herpesvirus 8 strain GK18) [
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YE
Receptor-Ligand Complex Structure
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PDB
7nxe
Recruitment of phospholipase C gamma 1 to the non-structural membrane protein pK15 of Kaposi Sarcoma-associated herpesvirus promotes its Src-dependent phosphorylation.
Resolution
2.1 Å
Binding residue
(original residue number in PDB)
R562 R586 E589 T596 H607 C646
Binding residue
(residue number reindexed from 1)
R17 R41 E44 T51 H62 C96
Enzymatic activity
Enzyme Commision number
3.1.4.11
: phosphoinositide phospholipase C.
External links
PDB
RCSB:7nxe
,
PDBe:7nxe
,
PDBj:7nxe
PDBsum
7nxe
PubMed
34143834
UniProt
P19174
|PLCG1_HUMAN 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (Gene Name=PLCG1)
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