Structure of PDB 7nvs Chain A Binding Site BS02

Receptor Information
>7nvs Chain A (length=1423) Species: 9823 (Sus scrofa) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SACPLRTIKRVQFGVLSPDELKRMSVTEGGIKYPETTEGGRPKLGGLMDP
RQGVIERTGRCQTCAGNMTECPGHFGHIELAKPVFHVGFLVKTMKVLRCV
CFFCSKLLVDSNNPKIKDILAKSKGQPKKRLTHVYDLCKGKNICEGGCGR
YQPRIRRSGLELYAEWKKILLSPERVHEIFKRISDEECFVLGMEPRYARP
EWMIVTVLPVPPLSVRPAVVMQGSARNQDDLTHKLADIVKINNQLRRNEQ
NGAAAHVIAEDVKLLQFHVATMVDNELPGLPRAMQKSGRPLKSLKQRLKG
KEGRVRGNLMGKRVDFSARTVITPDPNLSIDQVGVPRSIAANMTFAEIVT
PFNIDRLQELVRRGNSQYPGAKYIIRDNGDRIDLRFHPKPSDLHLQTGYK
VERHMCDGDIVIFNRQPTLHKMSMMGHRVRILPWSTFRLNLSVTTPYNAD
FDGDEMNLHLPQSLETRAEIQELAMVPRMIVTPQSNRPVMGIVQDTLTAV
RKFTKRDVFLERGEVMNLLMFLSTWDGKVPQPAILKPRPLWTGKQIFSLI
IPGHINCIRTHSTHPDDEDSGPYKHISPGDTKVVVENGELIMGILCKKSL
GTSAGSLVHISYLEMGHDITRLFYSNIQTVINNWLLIEGHTIGIGDSIAD
SKTYQDIQNTIKKAKQDVIEVIEKAHNNELEPTPGNTLRQTFENQVNRIL
NDARDKTGSSAQKSLSEYNNFKSMVVSGAKGSKINISQVIAVVGQQNVEG
KRIPFGFKHRTLPHFIKDDYGPESRGFVENSYLAGLTPTEFFFHAMGGRE
GLIDTAVKTAETGYIQRRLIKSMESVMVKYDATVRNSINQVVQLRYGEDG
LAGESVEFQNLATLKPSNKAFEKKFRFDYTNERALRRTLQEDLVKDVLSN
AHIQNELEREFERMREDREVLRVIFPTGDSKVVLPCNLLRMIWNAQKIFH
INPRLPSDLHPIKVVEGVKELSKKLVIVNGDDPLSRQAQENATLLFNIHL
RSTLCSRRMAEEFRLSGEAFDWLLGEIESKFNQAIAHPGEMVGALAAQSL
GEPATQMTLNKNVTLGVPRLKELINISKKPKTPSLTVFLLGQSARDAERA
KDILCRLEHTTLRKVTANTAIYYDPNPQSTVVAEDQEWVNVYYEMPDFDV
ARISPWLLRVELDRKHMTDRKLTMEQIAEKINAGFGDDLNCIFNDDNAEK
LVLRIRIMNSDENKMDDDVFLRCIESNMLTDMTLQGIEQISKVYMHLPQT
DNKKKIIITEDGEFKALQEWILETDGVSLMRVLSEKDVDPVRTTSNDIVE
IFTVLGIEAVRKALERELYHVISFDGSYVNYRHLALLCDTMTCRGHLMAI
TRHGVNRQDTGPLMKCSFEETVDVLMEAAAHGESDPMKGVSENIMLGQLA
PAGTGCFDLLLDAEKCKYGMEIP
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain7nvs Chain A Residue 2002 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7nvs Structures of mammalian RNA polymerase II pre-initiation complexes.
Resolution2.8 Å
Binding residue
(original residue number in PDB)		C111 C114 C154
Binding residue
(residue number reindexed from 1)		C101 C104 C144
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0016779 nucleotidyltransferase activity
GO:0046872 metal ion binding
Biological Process
GO:0006351 DNA-templated transcription
GO:0006366 transcription by RNA polymerase II
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex
GO:0005634 nucleus
GO:0031981 nuclear lumen
GO:0032991 protein-containing complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7nvs, PDBe:7nvs, PDBj:7nvs
PDBsum7nvs
PubMed33902107
UniProtA0A7M4DUC2

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