Structure of PDB 7nv1 Chain A Binding Site BS02

Receptor Information
>7nv1 Chain A (length=430) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KGSRFYGNELKKEKQVNQRIENMMQQKAQITSQQLRKAQLQVDRFAMELE
QSRNLSNTIVHIDMDAFYAAVEMRDNPELKDKPIAVGSMSMLSTSNYHAR
RFGVRAAMPGFIAKRLCPQLIIVPPNFDKYRAVSKEVKEILADYDPNFMA
MSLDEAYLNITKHLEERQNWPEDKRRYFIKNSVVFGTSAQEVVKEIRFRI
EQKTTLTASAGIAPNTMLAKVCSDKNKPNGQYQILPNRQAVMDFIKDLPI
RKVSGIGKVTEKMLKALGIITCTELYQQRALLSLLFSETSWHYFLHISLG
LGSTHLTERKSMSVERTFSEINKAEEQYSLCQELCSELAQDLQKERLKGR
TVTIKLKNVNFEVKTRASTVSSVVSTAEEIFAIAKELLKTEIDADFPHPL
RLRLMGVRISSFPNEEDRKHQQRSIIGFLQ
Ligand information
Receptor-Ligand Complex Structure
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PDB7nv1 Cryo-EM structure of human Pol kappa bound to DNA and mono-ubiquitylated PCNA.
Resolution6.4 Å
Binding residue
(original residue number in PDB)		F49 M135 P153 F155 T390 R413 S415 S417 T421 R507
Binding residue
(residue number reindexed from 1)		F5 M91 P109 F111 T289 R309 S311 S313 T317 R403
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003684 damaged DNA binding
GO:0003887 DNA-directed DNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0006259 DNA metabolic process
GO:0006260 DNA replication
GO:0006281 DNA repair
GO:0006297 nucleotide-excision repair, DNA gap filling
GO:0006974 DNA damage response
GO:0034644 cellular response to UV
GO:0042276 error-prone translesion synthesis
GO:0071897 DNA biosynthetic process
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0016604 nuclear body
GO:0090734 site of DNA damage

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7nv1, PDBe:7nv1, PDBj:7nv1
PDBsum7nv1
PubMed34667155
UniProtQ9UBT6|POLK_HUMAN DNA polymerase kappa (Gene Name=POLK)

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