Structure of PDB 7ne3 Chain A Binding Site BS02

Receptor Information
>7ne3 Chain A (length=416) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SCRCVIIEKDEGPFYTHLGAGPNVAAIREIMEERFGQKGKAIRIERVIYT
GKEGKSSQGCPIAKWVVRRSSSEEKLLCLVRERAGHTCEAAVIVILILVW
EGIPLSLADKLYSELTETLRKYGTLTNRRCALNEERTCACQGLDPETCGA
SFSFGCSWSMYYNGCKFARSKIPRKFKLLGDDPKEEEKLESHLQNLSTLM
APTYKKLAPDAYNNQIEYEHRAPECRLGLKEGRPFSGVTACLDFCAHAHR
DLHNMQNGSTLVCTLTREDNREFGGKPEDEQLHVLPLYKVSDVDEFGSVE
AQEEKKRSGAIQVLSSFRRKVRMLAEPVKTCRGSDEVWSDSEQSFLDPDI
GGVAVAPTHGSILIECAKRELHATTPLKNPNRNHPTRISLVFYQHKSMNE
PKHGLALWEAKMAEKA
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7ne3 Pronounced sequence specificity of the TET enzyme catalytic domain guides its cellular function.
Resolution2.26 Å
Binding residue
(original residue number in PDB)		W1291 M1293 Y1294 N1296 L1385 K1905
Binding residue
(residue number reindexed from 1)		W158 M160 Y161 N163 L252 K396
Enzymatic activity
Enzyme Commision number 1.14.11.80: methylcytosine dioxygenase.
Gene Ontology
Molecular Function
GO:0070579 5-methylcytosine dioxygenase activity
Biological Process
GO:0141166 chromosomal 5-methylcytosine DNA demethylation pathway

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Molecular Function
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Biological Process
External links
PDB RCSB:7ne3, PDBe:7ne3, PDBj:7ne3
PDBsum7ne3
PubMed36070377
UniProtQ6N021|TET2_HUMAN Methylcytosine dioxygenase TET2 (Gene Name=TET2)

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