Structure of PDB 7n94 Chain A Binding Site BS02

Receptor Information

>7n94 Chain A (length=232) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

HITILTLNINGLNSAIKRHRLASWIKSQDPSVCCIQETHLTCRDTHRLKI
KGWRKIYQANGKQKKAGVAILVSDKTDFKPTKIKRDKEGHYIMVKGSIQQ
EELTILNIYAPNTGAPRFIKQVLSDLQRDLDSHTLIMGAFNTPLSTLDRS
TRQKVNKDTQELNSALHQADLIDIYRTLHPKSTEYTFFSAPHHTYSKIDH
IVGSKALLSKCKRTEIITNKLSDHSAIKLELR

Ligand information

>7n94 Chain E (length=17) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

agcccttaaaaaggagc

Receptor-Ligand Complex Structure

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Structure summary

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PDB	7n94 Structural dissection of sequence recognition and catalytic mechanism of human LINE-1 endonuclease.
Resolution	2.85 Å
Binding residue (original residue number in PDB)	N16 N19 K23 H45 K70 P197
Binding residue (residue number reindexed from 1)	N10 N13 K17 H39 K64 P191

Enzymatic activity

Enzyme Commision number

2.7.7.49: RNA-directed DNA polymerase.
3.1.21.-

Gene Ontology

	Molecular Function
GO:0003824	catalytic activity

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Molecular Function

External links

PDB	RCSB:7n94, PDBe:7n94, PDBj:7n94
PDBsum	7n94
PubMed	34554261
UniProt	O00370\|LORF2_HUMAN LINE-1 retrotransposable element ORF2 protein

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