Structure of PDB 7n8s Chain A Binding Site BS02

Receptor Information
>7n8s Chain A (length=232) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
HITILTLNINGLNSAIKRHRLASWIKSQDPSVCCIQETHLTCRDTHRLKI
KGWRKIYQANGKQKKAGVAILVSDKTDFKPTKIKRDKEGHYIMVKGSIQQ
EELTILNIYAPNTGAPRFIKQVLSDLQRDLDSHTLIMGAFNTPLSTLDRS
TRQKVNKDTQELNSALHQADLIDIYRTLHPKSTEYTFFSAPHHTYSKIDH
IVGSKALLSKCKRTEIITNKLSDHSAIKLELR
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB7n8s Structural dissection of sequence recognition and catalytic mechanism of human LINE-1 endonuclease.
Resolution2.79 Å
Binding residue
(original residue number in PDB)		E43 K71 Y115 N118 N147 R155 T157 F193 H198 T200 S202 I204
Binding residue
(residue number reindexed from 1)		E37 K65 Y109 N112 N141 R149 T151 F187 H192 T194 S196 I198
Enzymatic activity
Enzyme Commision number 2.7.7.49: RNA-directed DNA polymerase.
3.1.21.-
Gene Ontology
Molecular Function
GO:0003824 catalytic activity

View graph for
Molecular Function
External links
PDB RCSB:7n8s, PDBe:7n8s, PDBj:7n8s
PDBsum7n8s
PubMed34554261
UniProtO00370|LORF2_HUMAN LINE-1 retrotransposable element ORF2 protein

[Back to BioLiP]