Structure of PDB 7mvs Chain A Binding Site BS02

Receptor Information
>7mvs Chain A (length=674) Species: 1280 (Staphylococcus aureus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GKLADCSSKSPEECEIFLVEGDSAGGSTKSGRDSRTQAILPLRGKILNVE
KARLDRILNNNEIRQMITAFGTGIGGDFDLAKARYHKIVIMTDADVDGAH
IRTLLLTFFYRFMRPLIEAGYVYIAQPPTGYKGLGEMNADQLWETTMNPE
HRALLQVKLEDAIEADQTFEMLMGDVVENRRQFIEDNAVYARINERNITS
EMRESFLDYAMSVIVARALPDVRDGLKPVHRRILYGLNEQGMTPDKSYKK
SARIVGDVMGKYHPHGDSSIYEAMVRMAQDFSYRYPLVDGQGNFGSMDGD
GAAAMRFTEARMTKITLELLRDINKDTIDFIDNYDGNEREPSVLPARFPN
LLANGASGIAVGMATNIPPHNLTELINGVLSLSKNPDISIAELMEDIEGP
DFPTAGLILGKSGIRRAYETGRGSIQMRSRAVIEERGGGRQRIVVTEIPF
QVNKARMIEKIAELVRDKKIDGITDLRDETSLRTGVRVVIDVRKDANASV
ILNNLYKQTPLQTSFGVNMIALVNGRPKLINLKEALVHYLEHQKTVVRRR
TQYNLRKAKDRAHILEGLRIALDHIDEIISTIRESDTDKVAMESLQQRFK
LSEKQAQAILDMRLRRLTGLERDKIEAEYNELLNYISELETILADEEVLL
QLVRDELTEIRDRFGDDRRTEIQL
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7mvs Optimization of TopoIV Potency, ADMET Properties, and hERG Inhibition of 5-Amino-1,3-dioxane-Linked Novel Bacterial Topoisomerase Inhibitors: Identification of a Lead with In Vivo Efficacy against MRSA.
Resolution2.60137 Å
Binding residue
(original residue number in PDB)		K53 L55 N56 K59 R64 H108 V185 R188 R323 F324 I376 A377 G379 M380 R439
Binding residue
(residue number reindexed from 1)		K45 L47 N48 K51 R56 H100 V177 R180 R306 F307 I359 A360 G362 M363 R422
Enzymatic activity
Enzyme Commision number 5.6.2.2: DNA topoisomerase (ATP-hydrolyzing).
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003918 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
GO:0005524 ATP binding
Biological Process
GO:0006259 DNA metabolic process
GO:0006265 DNA topological change

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Molecular Function
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Biological Process
External links
PDB RCSB:7mvs, PDBe:7mvs, PDBj:7mvs
PDBsum7mvs
PubMed34614347
UniProtP0A0K8|GYRB_STAAU DNA gyrase subunit B (Gene Name=gyrB);
P20831

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