Structure of PDB 7mts Chain A Binding Site BS02

Receptor Information
>7mts Chain A (length=783) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KKVLTLEGDLVLGGLFPVHQKGGPAEDCGPVNEHRGIQRLEAMLFALDRI
NRDPHLLPGVRLGAHILDSCSKDTHALEQALDFVRASTAITGVIGGSYSD
VSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFFQAKAMA
EILRFFNWTYVSTVASEGDYGETGIEAFELEARARNICVATSEKVGRAMS
RAAFEGVVRALLQKPSARVAVLFTRSEDARELLAASQRLNASFTWVASDG
WGALESVVAGSEGAAEGAITIELASYPISDFASYFQSLDPWNNSRNPWFR
EFWEQRFRCSFRQRDCAAHSLRAVPFEQESKIMFVVNAVYAMAHALHNMH
RALCPNTTRLCDAMRPVNGRRLYKDFVLNVKFDAPFRPADTHNEVRFDRF
GDGIGRYNIFTYLRAGGRYRYQKVGYWAEGLTLDTSLIPWASPSAGPLPA
SRCSEPCLQNEVKSVQPGEVCCWLCIPCQPYEYRLDEFTCADCGLGYWPN
ASLTGCFELPQEYIRWGDAWAVGPVTIACLGALATLFVLGVFVRHNATPV
VKASGRELCYILLGGVFLCYCMTFIFIAKPSTAVCTLRRLGLGTAFSVCY
SALLTKTNRIARIFGGAREGAQRPRFISPASQVAICLALISGQLLIVVAW
LVVEAPGTGKETAPERREVVTLRCNHRDASMLGSLAYNVLLIALCTLYAF
KTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIFYVTSSDYRVQTTTMCVS
VSLSGSVVLGCLFAPKLHIILFQPQKNVVSHRA
Ligand information
Ligand IDGLU
InChIInChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m0/s1
InChIKeyWHUUTDBJXJRKMK-VKHMYHEASA-N
SMILES
SoftwareSMILES
ACDLabs 12.01O=C(O)C(N)CCC(=O)O
OpenEye OEToolkits 1.7.0C(CC(=O)O)C(C(=O)O)N
OpenEye OEToolkits 1.7.0C(CC(=O)O)[C@@H](C(=O)O)N
CACTVS 3.370N[C@@H](CCC(O)=O)C(O)=O
CACTVS 3.370N[CH](CCC(O)=O)C(O)=O
FormulaC5 H9 N O4
NameGLUTAMIC ACID
ChEMBLCHEMBL575060
DrugBankDB00142
ZINCZINC000001482113
PDB chain7mts Chain A Residue 902 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7mts G-protein activation by a metabotropic glutamate receptor.
Resolution3.2 Å
Binding residue
(original residue number in PDB)		R57 A166 T168 Y216 K377
Binding residue
(residue number reindexed from 1)		R35 A120 T122 Y170 K331
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0004930 G protein-coupled receptor activity
Biological Process
GO:0007186 G protein-coupled receptor signaling pathway
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7mts, PDBe:7mts, PDBj:7mts
PDBsum7mts
PubMed34194039
UniProtQ14416|GRM2_HUMAN Metabotropic glutamate receptor 2 (Gene Name=GRM2)

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