Structure of PDB 7m8a Chain A Binding Site BS02

Receptor Information
>7m8a Chain A (length=430) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GPHMATGQDRVVALVDMDCFFVQVEQRQNPHLRNKPCAVVQYKSWKGGGI
IAVSYEARAFGVTRSMWADDAKKLCPDLLLAQVRESRGKANLTKYREASV
EVMEIMSRFAVIERAAIDEAYVDLTSAVQERLQKLQGQPISADLLPSTYI
EGLPQGPTVQKEGMRKQGLFQWLDSLQIDNLTSPDLQLTVGAVIVEEMRA
AIERETGFQCSAGISHNKVLAKLACGLNKPNRQTLVSHGSVPQLFSQMPI
RKIRSLGGKLGASVIEILGIEYMGELTQFTESQLQSHFGEKNGSWLYAMC
RGIEHDPVKPRQLPKTIGCSKNFPGKTALATREQVQWWLLQLAQELEERL
TKDRNDNDRVATQLVVSIRVQGDKRLSSLRRCCALTRYDAHKMSHDAFTV
IKNCNTSGIQTEWSPPLTMLFLCATKFSAS
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7m8a Multiple deprotonation paths of the nucleophile 3'-OH in the DNA synthesis reaction.
Resolution1.91 Å
Binding residue
(original residue number in PDB)		F18 R61 A113 D115 K224 S257 G259 G260 K261 L262 R377 R382 C384
Binding residue
(residue number reindexed from 1)		F21 R64 A116 D118 K222 S255 G257 G258 K259 L260 R375 R380 C382
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0003684 damaged DNA binding
Biological Process
GO:0006281 DNA repair

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Molecular Function
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Biological Process
External links
PDB RCSB:7m8a, PDBe:7m8a, PDBj:7m8a
PDBsum7m8a
PubMed34088846
UniProtQ9Y253|POLH_HUMAN DNA polymerase eta (Gene Name=POLH)

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