Structure of PDB 7m7n Chain A Binding Site BS02

Receptor Information
>7m7n Chain A (length=425) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GPHMATGQDRVVALVDMDCFFVQVEQRQNPHLRNKPCAVVQYKSWKGGGI
IAVSYEARAFGVTRSMWADDAKKLCPDLLLAQVRESRGKANLTKYREASV
EVMEIMSRFAVIERASIDEAYVDLTSAVQERLQKLQGQPISADLLPSTYI
EGLPQGQKEGMRKQGLFQWLDSLQIDNLTSPDLQLTVGAVIVEEMRAAIE
RETGFQCSAGISHNKVLAKLACGLNKPNRQTLVSHGSVPQLFSQMPIRKI
RSLGGKLGASVIEILGIEYMGELTQFTESQLQSHFGEKNGSWLYAMCRGI
EHDPVKPRQLPKTIGCSKNFPGKTALATREQVQWWLLQLAQELEERLTKD
RNDNDRVATQLVVSIRVQGDKRLSSLRRCCALTRYDAHKMSHDAFTVIKN
CNTSGTEWSPPLTMLFLCATKFSAS
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7m7n Multiple deprotonation paths of the nucleophile 3'-OH in the DNA synthesis reaction.
Resolution1.31 Å
Binding residue
(original residue number in PDB)		S113 E116 K224 S257 G259 G260 K261 L262 R377 R382 C384
Binding residue
(residue number reindexed from 1)		S116 E119 K219 S252 G254 G255 K256 L257 R372 R377 C379
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0003684 damaged DNA binding
Biological Process
GO:0006281 DNA repair

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Molecular Function
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Biological Process
External links
PDB RCSB:7m7n, PDBe:7m7n, PDBj:7m7n
PDBsum7m7n
PubMed34088846
UniProtQ9Y253|POLH_HUMAN DNA polymerase eta (Gene Name=POLH)

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