Structure of PDB 7m4o Chain A Binding Site BS02

Receptor Information

>7m4o Chain A (length=116) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

AEKDDIKYRTSIEEKMTAARIRKCHKCGTGLIKSEGANRMSCRCGAQMCY
LCRVSINGYDHFCQHPRSPGAPCQECSRCSLWTDPTEDDEKLIEEIQKEA
EEEQKRKNGKRIGPPL

Ligand information

InChI=1S/Zn/q+2

PTFCDOFLOPIGGS-UHFFFAOYSA-N

SMILES

Software	SMILES
CACTVS 3.341	[Zn++]
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Zn+2]

Formula

Zn

Name

ZINC ION

PDB chain

7m4o Chain A Residue 802 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	7m4o Structural basis of K63-ubiquitin chain formation by the Gordon-Holmes syndrome RBR E3 ubiquitin ligase RNF216.
Resolution	2.21 Å
Binding residue (original residue number in PDB)	C700 C703 H712 C730
Binding residue (residue number reindexed from 1)	C49 C52 H61 C79
Annotation score	4

Enzymatic activity

Enzyme Commision number

2.3.2.27: RING-type E3 ubiquitin transferase.

External links

PDB	RCSB:7m4o, PDBe:7m4o, PDBj:7m4o
PDBsum	7m4o
PubMed	34998453
UniProt	Q9NWF9\|RN216_HUMAN E3 ubiquitin-protein ligase RNF216 (Gene Name=RNF216)

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