Structure of PDB 7lni Chain A Binding Site BS02

Receptor Information
>7lni Chain A (length=547) Species: 272563 (Clostridioides difficile 630) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ASGIYYTPKIIVDYIVKKTLKNHDIIKNPYPRILDISCGCGNFLLEVYDI
LYDLFEENIYELKKKYDENYWTVDNIHRHILNYCIYGADIDEKAISILKD
SLTNKKDESDIKINLFCCDSLKKKWRYKFDYIVGNPPYIGHKKLEKKYKK
FLLEKYSEVYKDKADLYFCFYKKIIDILKQGGIGSVITPRYFLESLSGKD
LREYIKSNVNVQEIVDFLGANIFKNIGVSSCILTFDKKKTKETYIDVFKI
KNEDICINKFETLEELLKSSKFEHFNINQRLLSDEWILVNKDDETFYNKI
QEKCKYSLEDIAISFQGIITGCDKAFILSKDDVKLNLVDDKFLKCWIKSK
NINKYIVDKSEYRLIYSNDIDNENTNKRILDEIIGLYKTKLENRRECKSG
IRKWYELQWGREKLFFERKKIMYPYKSNENRFAIDYDNNFSSADVYSFFI
KEEYLDKFSYEYLVGILNSSVYDKYFKITAKKMSKNIYDYYPNKVMKIRI
FRDNNYEEIENLSKQIISILLNKSIDKGKVEKLQIKMDNLIMDSLGI
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7lni Clostridioides difficile specific DNA adenine methyltransferase CamA squeezes and flips adenine out of DNA helix.
Resolution2.68 Å
Binding residue
(original residue number in PDB)		Y30 N165 Y168 K173 K193 Y221 S227 F253 I256 G257 Q346 W439 R441 K456 Y476 K511 M513 Y521 P522 N523
Binding residue
(residue number reindexed from 1)		Y5 N135 Y138 K143 K163 Y191 S197 F223 I226 G227 Q316 W409 R411 K426 Y446 K481 M483 Y491 P492 N493
Enzymatic activity
Enzyme Commision number 2.1.1.72: site-specific DNA-methyltransferase (adenine-specific).
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0008168 methyltransferase activity
GO:0009007 site-specific DNA-methyltransferase (adenine-specific) activity
Biological Process
GO:0006304 DNA modification
GO:0032259 methylation

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Molecular Function
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Biological Process
External links
PDB RCSB:7lni, PDBe:7lni, PDBj:7lni
PDBsum7lni
PubMed34103525
UniProtQ183J3

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