Structure of PDB 7lk7 Chain A Binding Site BS02

Receptor Information

>7lk7 Chain A (length=562) Species: 484018 (Phocaeicola plebeius DSM 17135)

KGTDVFKADSASIAQNYTIPEWFKDAKFGIFIHWGVYSVPAYGSEWYSRW
MYKEGHPINKYHVQTYGPLTKFGYKDFIPMFKAENFNADEWLAVVKSSGA
QYIVPVAEHHDGFAMYSSTFNKWNAVDMGPKRDIIGELKEATKKAGLRFG
LSSHRCENAWFYEYGMETPSDVQDTTITLYGERLHEPEGQGMTPYCGKYE
GSNERSRRQFLMHTYELIDKYQPELIWFDWTVGKYPFQPTFYKFMAYYYN
SALDWNKEVVVNTKFGYGDNIQVFDIERGKSDRIREYPWQTDTSVGKKSW
SYCVGEENKSPDHIIDDFVDIVSKNGNLLLNIGPKADGTITDEQKNVLAE
IGKWLKTNGEAIYGSRPWVIASEGHNAGTAGYMTDNTKTEYTADDIRFTT
CDNNLYAVSLAWTDGSVTIKSLATKYCRNVEIESVEMLGSSEKIDYKMTD
EGLVVNFPKNKPTEYAHVFKIKLKGVVVSKPLYDKVDNGCLITVRVANHN
AEDANVTLKSVVDGNEVSTQVAVKAKSEQWVKMQNKDVKSFDDMSCKFYF
NDNLTYENEFKK

Ligand information

• Ligand ID: GXL
• InChI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3+,4+,5-,6+/m0/s1
• InChIKey: WQZGKKKJIJFFOK-SXUWKVJYSA-N
• SMILES:
  OpenEye OEToolkits 1.5.0: C(C1C(C(C(C(O1)O)O)O)O)O
  CACTVS 3.341: OC[CH]1O[CH](O)[CH](O)[CH](O)[CH]1O
  CACTVS 3.341: OC[C@@H]1O[C@@H](O)[C@@H](O)[C@H](O)[C@@H]1O
  OpenEye OEToolkits 1.5.0: C([C@H]1[C@H]([C@H]([C@@H]([C@@H](O1)O)O)O)O)O
  ACDLabs 10.04: OC1C(O)C(OC(O)C1O)CO
• Formula: C6 H12 O6
• Name: alpha-L-galactopyranose;
  alpha-L-galactose;
  L-galactose;
  galactose
• ZINC: ZINC000001532549
• PDB chain: 7lk7 Chain A Residue 602

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7lk7 Metabolism of a hybrid algal galactan by members of the human gut microbiome.
• Resolution: 2.19 Å
• Binding residue (original residue number in PDB): H68 E80 W81 H144 H145 H189 W262 D264 K299 E312 D327 W335
• Binding residue (residue number reindexed from 1): H33 E45 W46 H109 H110 H154 W227 D229 K264 E277 D292 W300
• Annotation score: 2

Gene Ontology

Molecular Function

• GO:0004560 alpha-L-fucosidase activity

Biological Process

• GO:0005975 carbohydrate metabolic process
• GO:0006004 fucose metabolic process

External links

• PDB: RCSB:7lk7, PDBe:7lk7, PDBj:7lk7
• PDBsum: 7lk7
• PubMed: 35289327
• UniProt: B5CYA5