Structure of PDB 7lf4 Chain A Binding Site BS02

Receptor Information

>7lf4 Chain A (length=416) Species: 9606 (Homo sapiens)

SLEAIVQNASSDNQGIQLSAVQAARKLLSSDRNPPIDDLIKSGILPILVH
CLERDDNPSLQFEAAWALTNIASGTSEQTQAVVQSNAVPLFLRLLHSPHQ
NVCEQAVWALGNIIGDGPQCRDYVISLGVVKPLLSFISPSIPITFLRNVT
WVMVNLCRHKDPPPPMETIQEILPALCVLIHHTDVNILVDTVWALSYLTD
AGNEQIQMVIDSGIVPHLVPLLSHQEVKVQTAALRAVGNIVTGTDEQTQV
VLNCDALSHFPALLTHPKEKINKEAVWFLSNITAGNQQQVQAVIDANLVP
MIIHLLDKGDFGTQKEAAWAISNLTISGRKDQVAYLIQQNVIPPFCNLLT
VKDAQVVQVVLDGLSNILKMAEDEAETIGNLIEECGGLEKIEQLQNHENE
DIYKLAYEIIDQFFSS

Ligand information

>7lf4 Chain E (length=13) Species: 9606 (Homo sapiens)

EEKRKRTYETFKS

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7lf4 Differential recognition of canonical NF-kappa B dimers by Importin alpha 3.
• Resolution: 2.85 Å
• Binding residue (original residue number in PDB): K231 D271 R306 V312 T319 K344 W348 N352 A355 E387 W390
• Binding residue (residue number reindexed from 1): K160 D200 R235 V241 T248 K273 W277 N281 A284 E316 W319

Gene Ontology

Molecular Function

• GO:0005515 protein binding
• GO:0008139 nuclear localization sequence binding
• GO:0061608 nuclear import signal receptor activity

Biological Process

• GO:0006606 protein import into nucleus
• GO:0006607 NLS-bearing protein import into nucleus
• GO:0010467 gene expression
• GO:0014046 dopamine secretion
• GO:0015031 protein transport

Cellular Component

• GO:0005634 nucleus
• GO:0005643 nuclear pore
• GO:0005654 nucleoplasm
• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0031965 nuclear membrane
• GO:0042564 NLS-dependent protein nuclear import complex

External links

• PDB: RCSB:7lf4, PDBe:7lf4, PDBj:7lf4
• PDBsum: 7lf4
• PubMed: 35260573
• UniProt: O00629|IMA3_HUMAN Importin subunit alpha-3 (Gene Name=KPNA4)