Structure of PDB 7lde Chain A Binding Site BS02

Receptor Information
>7lde Chain A (length=776) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ANFPNNIQIGGLFPNQQSQEHAAFRFALSQLTEPPKLLPQIDIVNISDSF
EMTYRFCSQFSKGVYAIFGFYERRTVNMLTSFCGALHVCFITPSFPVDTS
NQFVLQLRPELQEALISIIDHYKWQTFVYIYDADRGLSVLQRVLDTAAEK
NWQVTAVNILTTTEEGYRMLFQDLEKKKERLVVVDCESERLNAILGQIVK
LEKNGIGYHYILANLGFMDIDLNKFKESGANVTGFQLVNYTDTIPARIMQ
QWRTSDARDHTRVDWKRPKYTSALTYDGVKVMAEAFQSLRRQRIDISRRG
NAGDCLANPAVPWGQGIDIQRALQQVRFEGLTGNVQFNEKGRRTNYTLHV
IEMKHDGIRKIGYWNEDDKFVPATYIVTTILEDPYVMLKKNANQFEGNDR
YEGYCVELAAEIAKHVGYSYRLEIVSDGKYGARDPDTKAWNGMVGELVYG
RADVAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDP
LAYEIWMCIVFAYIGVSVVLFLVSRFSNEFGIFNSLWFSLGAFMQQGCDI
SPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAK
QTEIAYGTLEAGSTKEFFRRSKIAVFEKMWTYMKSAEPSVFVRTTEEGMI
RVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSA
LRGPVNLAVLKLSEQGVLDKLKSKWWYDKGECGSKDSGSKDKTSALSLSN
VAGVFYILIGGLGLAMLVALIEFCYK
Ligand information
Ligand IDXVD
InChIInChI=1S/C14H8ClF3N2O2/c15-8-2-1-3-11(22-14(16,17)18)12(8)7-4-5-9-10(6-7)20-13(21)19-9/h1-6H,(H2,19,20,21)
InChIKeyCOBXSLRIXGQVGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 2.0.7c1cc(c(c(c1)Cl)c2ccc3c(c2)[nH]c(n3)O)OC(F)(F)F
CACTVS 3.385Oc1[nH]c2cc(ccc2n1)c3c(Cl)cccc3OC(F)(F)F
ACDLabs 12.01n3c2c(cc(c1c(cccc1Cl)OC(F)(F)F)cc2)nc3O
FormulaC14 H8 Cl F3 N2 O2
Name6-[2-chloro-6-(trifluoromethoxy)phenyl]-1H-benzimidazol-2-ol
ChEMBLCHEMBL4214902
DrugBank
ZINC
PDB chain7lde Chain G Residue 504 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7lde Hippocampal AMPA receptor assemblies and mechanism of allosteric inhibition.
Resolution3.9 Å
Binding residue
(original residue number in PDB)		M523 C524 F527
Binding residue
(residue number reindexed from 1)		M507 C508 F511
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005216 monoatomic ion channel activity
GO:0015276 ligand-gated monoatomic ion channel activity
GO:0038023 signaling receptor activity
Biological Process
GO:0006811 monoatomic ion transport
Cellular Component
GO:0016020 membrane

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7lde, PDBe:7lde, PDBj:7lde
PDBsum7lde
PubMed33981040
UniProtP23818|GRIA1_MOUSE Glutamate receptor 1 (Gene Name=Gria1)

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