Structure of PDB 7lbk Chain A Binding Site BS02

Receptor Information
>7lbk Chain A (length=137) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LPPAWQPFLKDHRISTFKNWPFLEGCACTPERMAEAGFIHCPTENEPDLA
QCFFCFKELEGWEPDDDPIEEHKKHSSGCAFLSVKKQFEELTLGEFLKLD
RERAKNKIAKETNNKKKEFEETAKKVRRAIEQLAAMD
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain7lbk Chain A Residue 201 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7lbk Tip60 acetylation of histone H3K4 temporally controls chromosome passenger complex localization.
Resolution2.7 Å
Binding residue
(original residue number in PDB)		C57 C60 H77 C84
Binding residue
(residue number reindexed from 1)		C52 C55 H72 C79
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0004869 cysteine-type endopeptidase inhibitor activity
GO:0005515 protein binding
GO:0008017 microtubule binding
GO:0019899 enzyme binding
GO:0031267 small GTPase binding
GO:0042802 identical protein binding
GO:0046872 metal ion binding
GO:0051087 protein-folding chaperone binding
Biological Process
GO:0000278 mitotic cell cycle
GO:0000281 mitotic cytokinesis
GO:0006468 protein phosphorylation
GO:0006915 apoptotic process
GO:0007059 chromosome segregation
GO:0007605 sensory perception of sound
GO:0008284 positive regulation of cell population proliferation
GO:0010466 negative regulation of peptidase activity
GO:0031503 protein-containing complex localization
GO:0042981 regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0045892 negative regulation of DNA-templated transcription
GO:0051256 mitotic spindle midzone assembly
GO:0051301 cell division
GO:0090267 positive regulation of mitotic cell cycle spindle assembly checkpoint
GO:0090307 mitotic spindle assembly
GO:1901970 positive regulation of mitotic sister chromatid separation
GO:1902425 positive regulation of attachment of mitotic spindle microtubules to kinetochore
GO:1903490 positive regulation of mitotic cytokinesis
Cellular Component
GO:0000228 nuclear chromosome
GO:0000775 chromosome, centromeric region
GO:0000776 kinetochore
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005694 chromosome
GO:0005737 cytoplasm
GO:0005819 spindle
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005874 microtubule
GO:0015630 microtubule cytoskeleton
GO:0030496 midbody
GO:0032133 chromosome passenger complex
GO:1990713 survivin complex

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Molecular Function
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Cellular Component
External links
PDB RCSB:7lbk, PDBe:7lbk, PDBj:7lbk
PDBsum7lbk
PubMed35653296
UniProtO15392|BIRC5_HUMAN Baculoviral IAP repeat-containing protein 5 (Gene Name=BIRC5)

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