Structure of PDB 7l3l Chain A Binding Site BS02

Receptor Information
>7l3l Chain A (length=141) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SLDFEPSIEYQFVERLEERYKCAFCHSVLHNPHQTGCGHRFCQHCILSLR
ELNTVPICPVDKEVIKSQEVFKDNCCKREVLNLYVYCSNAPGCNAKVILG
RYQDHLQQCLFQPVQCSNEKCREPVLRKDLKEHLSASCQFR
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain7l3l Chain A Residue 202 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7l3l The structure and ubiquitin binding properties of TRAF RING heterodimers.
Resolution2.8 Å
Binding residue
(original residue number in PDB)		C60 H62 C81 D84
Binding residue
(residue number reindexed from 1)		C37 H39 C58 D61
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005164 tumor necrosis factor receptor binding
GO:0008270 zinc ion binding
Biological Process
GO:0043123 positive regulation of canonical NF-kappaB signal transduction

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Molecular Function
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Biological Process
External links
PDB RCSB:7l3l, PDBe:7l3l, PDBj:7l3l
PDBsum7l3l
PubMed33539883
UniProtO00463|TRAF5_HUMAN TNF receptor-associated factor 5 (Gene Name=TRAF5)

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