Structure of PDB 7l1f Chain A Binding Site BS02

Receptor Information
>7l1f Chain A (length=832) Species: 2697049 (Severe acute respiratory syndrome coronavirus 2) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
YRAFDIYNDKVAGFAKFLKETIYNLLKDCPAVAKHDLTKYTMADLVYALR
HFDEGNCDTLKEILVTYNCCDDDYFNKKDWYDFVENPDILRVYANLGERV
RQALLKTVQFCDAMRNAGIVGVLTLDNQDLNGNWYDFGDFIQTTPGSGVP
VVDSYYSLLMPILTLTRALTAESHVDTDLTKPYIKWDLLKYDFTEERLKL
FDRYFKYWDQTYHPNCVNCLDDRCILHCANFNVLFSTVFPPTSFGPLVRK
IFVDGVPFVVSTGYHFRELGVVHNQDVNLHSSRLSFKELLVYAADPAMHA
ASGNLLLDKRTTCFSVAALTNNVAFQTVKPGNFNKDFYDFAVSKGFFKEG
SSVELKHFFFAQDGNAAISDYDYYRYNLPTMCDIRQLLFVVEVVDKYFDC
YDGGCINANQVIVNNLDKSAGFPFNKWGKARLYYDSMSYEDQDALFAYTK
RNVIPTITQMNLKYAISAKNRARTVAGVSICSTMTNRQFHQKLLKSIAAT
RGATVVIGTSKFYGGWHNMLKTVYSDVENPHLMGWDYPKCDRAMPNMLRI
MASLVLARKHTTCCSLSHRFYRLANECAQVLSEMVMCGGSLYVKPGGTSS
GDATTAYANSVFNICQAVTANVNALLSTDGNKIADKYVRNLQHRLYECLY
RNRDVDTDFVNEFYAYLRKHFSMMILSDDAVVCFNSTYASQGLVASIKNF
KSVLYYQNNVFMSEAKCWTETDLTKGPHEFCSQHTMLVKQGDDYVYLPYP
DPSRILGAGCFVDDIVKTDGTLMIERFVSLAIDAYPLTKHPNQEYADVFH
LYLQYIRKLHDELNTSRYWEPEFYEAMYTPHT
Ligand information
Receptor-Ligand Complex Structure
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PDB7l1f Remdesivir is a delayed translocation inhibitor of SARS-CoV-2 replication.
Resolution3.89 Å
Binding residue
(original residue number in PDB)		N496 K500 S501 N543 G590 S592 Y595 G683 A685 Y689
Binding residue
(residue number reindexed from 1)		N414 K418 S419 N461 G508 S510 Y513 G601 A603 Y607
Enzymatic activity
Enzyme Commision number 2.1.1.56: mRNA (guanine-N(7))-methyltransferase.
2.1.1.57: methyltransferase cap1.
2.7.7.48: RNA-directed RNA polymerase.
2.7.7.50: mRNA guanylyltransferase.
3.1.13.-
3.4.19.12: ubiquitinyl hydrolase 1.
3.4.22.-
3.4.22.69: SARS coronavirus main proteinase.
3.6.4.12: DNA helicase.
3.6.4.13: RNA helicase.
4.6.1.-
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003968 RNA-dependent RNA polymerase activity
GO:0005524 ATP binding
Biological Process
GO:0006351 DNA-templated transcription
GO:0039694 viral RNA genome replication

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:7l1f, PDBe:7l1f, PDBj:7l1f
PDBsum7l1f
PubMed33631104
UniProtP0DTD1|R1AB_SARS2 Replicase polyprotein 1ab (Gene Name=rep)

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