Structure of PDB 7kyc Chain A Binding Site BS02

Receptor Information
>7kyc Chain A (length=1178) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ELRTVYYNMPLPKDMIDEEGNPIMQYPRNKIRTTKYTPLTFLPKNILFQF
HNFANVYFLVLIILGAFQIFGVTNPGLSAVPLVVIVIITAIKDAIEDSRR
TVLDLEVNNTKTHILEGVENENVSNIVDRSLPPRTDCKFAKNYWKGVKVG
DIVRIHNNDEIPADIILLSTSDTDGACYVETKNLDGETNLKVRQSLKCTN
TIRTSKDIARTKFWIESEGPHSNLYTYQGNMKWRNLADGEIRNEPITINN
VLLRGCTLRNTKWAMGVVMFTGGDTKIMLNSGITPTKKSRISRELNFSVV
INFVLLFILCFVSGIANGVYYDKKGRSRFSYEFGTIAGSAATNGFVSFWV
AVILYQSLVPISLYISVEIIKTAQAAFIYGDVLLYNAKLDYPCTPKSWNI
SDDLGQVEYIFSDKTGTLTQNVMEFKKCTINGVSYGRAYTEALAGLRKRQ
GIDVETEGRREKAEIAKDRDTMIDELRALSGNSQFYPEEVTFVSKEFVRD
LKGASGEVQQRCCEHFMLALALCHSVLVEANPDNPKKLDLKAQSPDEAAL
VATARDVGFSFVGKTKKGLIIEMQGIQKEFEILNILEFNSSRKRMSCIVK
IPGEPRALLICKGADSIIYSRLSRQSNSEAILEKTALHLEQYATEGLRTL
CIAQRELSWSEYEKWNEKYDIAAASLANREDELEVVADSIERELILLGGT
AIEDRLQDGVPDCIELLAEAGIKLWVLTGDKVETAINIGFSCNLLNNEME
LLVIKTTGDDVKEFGSEPSEIVDALLSKYLKEYFNLTGSEEEIFEAKKDH
EFPKGNYAIVIDGDALKLALYGEDIRRKFLLLCKNCRAVLCCRVSPSQKA
AVVKLVKDSLDVMTLAIGDGSNDVAMIQSADVGIGIAGEEGRQAVMCSDY
AIGQFRYLARLVLVHGRWSYKRLAEMIPEFFYKNMIFALALFWYGIYNDF
DGSYLYEYTYMMFYNLAFTSLPVIFLGILDQDVNDTISLVVPQLYRVGIL
RKEWNQRKFLWYMLDGLYQSIICFFFPYLVYHKNMIVTSNGLGLDHRYFV
GVYVTTIAVISCNTYVLLHQYRWDWFSGLFIALSCLVVFAWTGIWSSAIA
SREFFKAAARIYGAPSFWAVFFVAVLFCLLPRFTYDSFQKFFYPTDVEIV
REMWQHGHFDHYPPGYDPTDPNRPKVTK
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain7kyc Chain A Residue 1602 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7kyc Transport mechanism of P4 ATPase phosphatidylcholine flippases.
Resolution2.8 Å
Binding residue
(original residue number in PDB)		D667 T669 D1130
Binding residue
(residue number reindexed from 1)		D413 T415 D869
Annotation score1
Enzymatic activity
Enzyme Commision number 7.6.2.1: P-type phospholipid transporter.
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0000287 magnesium ion binding
GO:0005215 transporter activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity
GO:0042802 identical protein binding
GO:0046872 metal ion binding
GO:0090554 phosphatidylcholine floppase activity
GO:0090555 phosphatidylethanolamine flippase activity
GO:0090556 phosphatidylserine floppase activity
GO:0140326 ATPase-coupled intramembrane lipid transporter activity
GO:0140345 phosphatidylcholine flippase activity
GO:0140346 phosphatidylserine flippase activity
GO:0140351 glycosylceramide flippase activity
Biological Process
GO:0006869 lipid transport
GO:0006886 intracellular protein transport
GO:0006897 endocytosis
GO:0007163 establishment or maintenance of cell polarity
GO:0015914 phospholipid transport
GO:0045332 phospholipid translocation
GO:0099040 ceramide translocation
GO:0140331 aminophospholipid translocation
Cellular Component
GO:0005739 mitochondrion
GO:0005768 endosome
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0005933 cellular bud
GO:0005935 cellular bud neck
GO:0010008 endosome membrane
GO:0016020 membrane
GO:0030428 cell septum
GO:0070867 mating projection tip membrane
GO:0071944 cell periphery
GO:1990531 phospholipid-translocating ATPase complex

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Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7kyc, PDBe:7kyc, PDBj:7kyc
PDBsum7kyc
PubMed33320091
UniProtP32660|ATC5_YEAST Phospholipid-transporting ATPase DNF1 (Gene Name=DNF1)

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