Structure of PDB 7kya Chain A Binding Site BS02

Receptor Information
>7kya Chain A (length=1174) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NRSDELRTVYYNLPLPEDMLDEDGLPLAVYPRNKIRTTKYTPLTFFPKNI
LFQFHNFANIYFLILLILGAFQIFGVTNPGFASVPLIVIVIITAIKDGIE
DSRRTVLDLEVNNTRTHILSGVKNENVANLVDRTLQPNPECRFAKDYWKN
VKVGDIVRVHNNDEIPADMILLSTSDVDGACYVETKNLDGETNLKVRQSL
KCSKIIKSSRDITRTKFWVESEGPHANLYSYQGNFKWQDTQNGNIRNEPV
NINNLLLRGCTLRNTKWAMGMVIFTGDDTKIMINAGVTPTKKSRISRELN
FSVILNFVLLFILCFTAGIVNGVYYKQKPRSRDYFEFASTNGFVSFWVAV
ILYQSLVPISLYISVEIIKTAQAIFIYTDVLLYNAKLDYPCTPKSWNISD
DLGQIEYIFSDKTGTLTQNVMEFKKCTINGVSYGRAYTEALAGLRKRQGV
DVESEGRREKEEIAKDRETMIDELRSMSDNTQFCPEDLTFVSKEIVEDLK
GSSGDHQQKCCEHFLLALALCHSVLVEPNKDDPKKLDIKAQSPDESALVS
TARQLGYSFVGSSKSGLIVEIQGVQKEFQVLNVLEFNSSRKRMSCIIKIP
GEPKALLICKGADSVIYSRLDRTQNDATLLEKTALHLEEYATEGLRTLCL
AQRELTWSEYERWVKTYDVAAASVTNREEELDKVTDVIERELILLGGTAI
EDRLQDGVPDSIALLAEAGIKLWVLTGDKVETAINIGFSCNVLNNDMELL
VVKASGEDVEEFGSDPIQVVNNLVTKYLREKFGMSGSEEELKEAKREHGL
PQGNFAVIIDGDALKVALNGEEMRRKFLLLCKNCKAVLCCRVSPAQKAAV
VKLVKKTLDVMTLAIGDGSNDVAMIQSADVGVGIAGEEGRQAVMCSDYAI
GQFRYVTRLVLVHGKWCYKRLAEMIPQFFYKNVIFTLSLFWYGIYNNFDG
SYLFEYTYLTFYNLAFTSVPVILLAVLDQDVSDTVSMLVPQLYRVGILRK
EWNQTKFLWYMLDGVYQSVICFFFPYLAYHKNMVVTENGLGLDHRYFVGV
FVTAIAVTSCNFYVFMEQYRWDWFCGLFICLSLAVFYGWTGIWTSSSSSN
EFYKGAARVFAQPAYWAVLFVGVLFCLLPRFTIDCIRKIFYPKDIEIVRE
MWLRGDFDLYPQGYDPTDPSRPRI
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain7kya Chain A Residue 1702 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7kya Transport mechanism of P4 ATPase phosphatidylcholine flippases.
Resolution3.5 Å
Binding residue
(original residue number in PDB)		T714 D1173
Binding residue
(residue number reindexed from 1)		T413 D867
Annotation score1
Enzymatic activity
Enzyme Commision number 7.6.2.1: P-type phospholipid transporter.
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0000287 magnesium ion binding
GO:0005215 transporter activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0015247 aminophospholipid flippase activity
GO:0016887 ATP hydrolysis activity
GO:0046872 metal ion binding
GO:0090554 phosphatidylcholine floppase activity
GO:0090555 phosphatidylethanolamine flippase activity
GO:0090556 phosphatidylserine floppase activity
GO:0140326 ATPase-coupled intramembrane lipid transporter activity
GO:0140346 phosphatidylserine flippase activity
GO:0140351 glycosylceramide flippase activity
Biological Process
GO:0006869 lipid transport
GO:0006897 endocytosis
GO:0007163 establishment or maintenance of cell polarity
GO:0015031 protein transport
GO:0015914 phospholipid transport
GO:0045332 phospholipid translocation
GO:0099040 ceramide translocation
GO:0140331 aminophospholipid translocation
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005886 plasma membrane
GO:0005935 cellular bud neck
GO:0016020 membrane
GO:0070867 mating projection tip membrane
GO:0071944 cell periphery
GO:1990531 phospholipid-translocating ATPase complex

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Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7kya, PDBe:7kya, PDBj:7kya
PDBsum7kya
PubMed33320091
UniProtQ12675|ATC4_YEAST Phospholipid-transporting ATPase DNF2 (Gene Name=DNF2)

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