Structure of PDB 7ktm Chain A Binding Site BS02
Receptor Information
>7ktm Chain A (length=327) Species:
9606
(Homo sapiens) [
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WMPAYACQRPTPLTHHNTGLSEALEILAEAAGFEGSEGRLLTFCRAASVL
KALPSPVTTLSQLQGLPHFGEHSSRVVQELLEHGVCEEVERVRRSERYQT
MKLFTQIFGVGVKTADRWYREGLRTLDDLREQPQKLTQQQKAGLQHHQDL
STPVLRSDVDALQQVVEEAVGQALPGATVTLTGGFRRGKLQGHDVDFLIT
HPKEGQEAGLLPRVMCRLQDQGLILYHQAFERSFCIFRLPQPGSWKAVRV
DLVVAPVSQFPFALLGWTGSDLFQRELRRFSRKEKGLWLNSHGLFDPEQK
TFFQAASEEDIFRHLGLEYLPPEQRNA
Ligand information
>7ktm Chain P (length=5) [
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cgtag
Receptor-Ligand Complex Structure
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PDB
7ktm
Watching a double strand break repair polymerase insert a pro-mutagenic oxidized nucleotide.
Resolution
1.528 Å
Binding residue
(original residue number in PDB)
F244 G245 V246 G247 T250 H329 D330 D332 R416 G433 W434 T435 G436 D438 R445
Binding residue
(residue number reindexed from 1)
F108 G109 V110 G111 T114 H193 D194 D196 R249 G266 W267 T268 G269 D271 R278
Enzymatic activity
Enzyme Commision number
2.7.7.7
: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0003677
DNA binding
GO:0003887
DNA-directed DNA polymerase activity
GO:0016779
nucleotidyltransferase activity
GO:0034061
DNA polymerase activity
Biological Process
GO:0006281
DNA repair
Cellular Component
GO:0005634
nucleus
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Molecular Function
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Biological Process
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Cellular Component
External links
PDB
RCSB:7ktm
,
PDBe:7ktm
,
PDBj:7ktm
PDBsum
7ktm
PubMed
33824325
UniProt
Q9NP87
|DPOLM_HUMAN DNA-directed DNA/RNA polymerase mu (Gene Name=POLM)
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