Structure of PDB 7kr4 Chain A Binding Site BS02

Receptor Information
>7kr4 Chain A (length=639) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SNDMDPSGYNPAKNNYHPVEDACWKPGQKVPYLAVARTFEKIEEVSARLR
MVETLSNLLRSVVALSPPDLLPVLYLSLNHLGPPQQGLALGVGDGVLLKA
VAQATGRQLESVRAEAAEKGDVGLVAENSRSTPPPPLTASGVFSKFRDIA
RLTGSASTAKKIDIIKGLFVACRHSEARFIARSLSGRLRLGLAEQSVLAA
LSQAVSLTPPGQEFPPAMVDAGKGKTAEARKTWLEEQGMILKQTFCEVPD
LDRIIPVLLEHGLERLPEHCKLSPGIPLKPMLAHPTRGISEVLKRFEEAA
FTCEYKYDGQRAQIHALEGGEVKIFSRNQADNTGKYPDIISRIPKIKLPS
VTSFILDTEAVAWDREKKQIQPFQVLTTRKRKEVDASEIQVQVCLYAFDL
IYLNGESLVREPLSRRRQLLRENFVETEGEFVFATSLDTKDIEQIAEFLE
QSVKDSCEGLMVKTLDVDATYEIAKRSHNWLKLKKDYLDGVGDTLDLVVI
GAYLGRGKRAGRYGGFLLASYDEDSEELQAICKLGTGFSDEELEEHHQSL
KALVLPSPRPYVRIDGAVIPDHWLDPSAVWEVKCADLSLSPIYPAARGLV
DSDKGISLRFPRFIRVREDKQPEQATTSAQVACLYRKQS
Ligand information
Receptor-Ligand Complex Structure
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PDB7kr4 High-fidelity DNA ligation enforces accurate Okazaki fragment maturation during DNA replication.
Resolution2.2 Å
Binding residue
(original residue number in PDB)		S303 R305 R549 Y749 T798 G799 F800 S801 D802 F872 R874
Binding residue
(residue number reindexed from 1)		S46 R48 R287 Y487 T536 G537 F538 S539 D540 F610 R612
Enzymatic activity
Enzyme Commision number 6.5.1.1: DNA ligase (ATP).
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003909 DNA ligase activity
GO:0003910 DNA ligase (ATP) activity
GO:0005524 ATP binding
Biological Process
GO:0006281 DNA repair
GO:0006310 DNA recombination
GO:0071897 DNA biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:7kr4, PDBe:7kr4, PDBj:7kr4
PDBsum7kr4
PubMed33473124
UniProtP18858|DNLI1_HUMAN DNA ligase 1 (Gene Name=LIG1)

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