Structure of PDB 7kpr Chain A Binding Site BS02

Receptor Information
>7kpr Chain A (length=403) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LPLRFPYGRPEFLGLSQDEVECSADHIARPILILKETRRLPWATGYAEVI
NAGKSTHNEDQASCEVLTVKKVSCHYWSLFDGHAGSGAAVVASRLLQHHI
TEQLQDIVDILKNSAVLPPTFFTEKKIPHECLVIGALESAFKEMDLQIER
ERSSYNISGGCTALIVICLLGKLYVANAGASRAIIIRNGEIIPMSSEFTP
ETERQRLQYLAFMQPHLLGNEFTHLEFPRRVQRKELGKKMLYRDFNMTGW
AYKTIEDEDLKFPLIYGEGKKARVMATIGVTRGLGDHDLKVHDSNIYIKP
FLSSAPEVRIYDLSKYDHGSDDVLILATDGLWDVLSNEEVAEAITQFLPN
CDPDDPHRYTLAAQDLVMRARGVLKDRGWRISNDRLGSGDDISVYVIPLI
HGN
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain7kpr Chain A Residue 602 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7kpr Structural basis for the specificity of PPM1H phosphatase for Rab GTPases.
Resolution3.09 Å
Binding residue
(original residue number in PDB)		D151 D437 D498
Binding residue
(residue number reindexed from 1)		D81 D329 D390
Annotation score1
Enzymatic activity
Enzyme Commision number 3.1.3.16: protein-serine/threonine phosphatase.
Gene Ontology
Molecular Function
GO:0004721 phosphoprotein phosphatase activity
GO:0004722 protein serine/threonine phosphatase activity
GO:0004741 [pyruvate dehydrogenase (acetyl-transferring)]-phosphatase activity
GO:0005515 protein binding
GO:0017018 myosin phosphatase activity
GO:0042802 identical protein binding
Biological Process
GO:0006470 protein dephosphorylation
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0045202 synapse
GO:0098978 glutamatergic synapse

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7kpr, PDBe:7kpr, PDBj:7kpr
PDBsum7kpr
PubMed34580980
UniProtQ9ULR3|PPM1H_HUMAN Protein phosphatase 1H (Gene Name=PPM1H)

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