Structure of PDB 7kjc Chain A Binding Site BS02

Receptor Information

>7kjc Chain A (length=376) Species: 9606 (Homo sapiens)

GPGDPHTYEDPNQAVLKFTTEIHPSCVTRQKVIGAGEFGEVYKGMLKTSK
EVPVAIKTLKAGYTEKQRVDFLGEAGIMGQFSHHNIIRLEGVISKYKPMM
IITEYMENGALDKFLREKDGEFSVLQLVGMLRGIAAGMKYLANMNYVHRD
LAARNILVNSNLVCKVSDFGLSRVLEDDPEATYKIPIRWTAPEAISYRKF
TSASDVWSFGIVMWEVMTYGERPYWELSNHEVMKAINDGFRLPTPMDCPS
AIYQLMMQCWQQERARRPKFADIVSILDKLIRAPDSLKTLADFDPRVSIR
LPSTPFRTVSEWLESIKMQQYTEHFMAAGYTAIEKVVQMTNDDIKRIGVR
LPGHQKRIAYSLLGLKDQVNTVGIPI

Ligand information

• Ligand ID: MG
• InChI: InChI=1S/Mg/q+2
• InChIKey: JLVVSXFLKOJNIY-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mg+2]
  CACTVS 3.341: [Mg++]
• Formula: Mg
• Name: MAGNESIUM ION
• DrugBank: DB01378
• PDB chain: 7kjc Chain A Residue 1002

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7kjc Regulation of the EphA2 receptor intracellular region by phosphomimetic negative charges in the kinase-SAM linker.
• Resolution: 2.3 Å
• Binding residue (original residue number in PDB): E663 D757
• Binding residue (residue number reindexed from 1): E74 D168
• Annotation score: 1

Enzymatic activity

• Catalytic site (original residue number in PDB): D739 A741 R743 N744 D757 P780
• Catalytic site (residue number reindexed from 1): D150 A152 R154 N155 D168 P186
• Enzyme Commision number: 2.7.10.1: receptor protein-tyrosine kinase.

Gene Ontology

Molecular Function

• GO:0004672 protein kinase activity
• GO:0004713 protein tyrosine kinase activity
• GO:0005524 ATP binding

Biological Process

• GO:0006468 protein phosphorylation

External links

• PDB: RCSB:7kjc, PDBe:7kjc, PDBj:7kjc
• PDBsum: 7kjc
• PubMed: 34857764
• UniProt: P29317|EPHA2_HUMAN Ephrin type-A receptor 2 (Gene Name=EPHA2)