Structure of PDB 7kfn Chain A Binding Site BS02

Receptor Information
>7kfn Chain A (length=384) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LHLPQVLADAVSRLVLGKFGDLTDNFSSPHARRKVLAGVVMTTGTDVKDA
KVISVSTGTKCINGEYMSDRGLALNDCHAEIISRRSLLRFLYTQLELYLN
NKDDQKRSIFQKSERGGFRLKENVQFHLYISTSPCGDARIFSPHEPILEE
PADRHPNRKARGQLRTKIESGEGTIPVRSNASIQTWDGVLQGERLLTMSC
SDKIARWNVVGIQGSLLSIFVEPIYFSSIILGSLYHGDHLSRAMYQRISN
IEDLPPLYTLNKPLLSGISNAEARQPGKAPNFSVNWTVGDSAIEVINATT
GKDELGRASRLCKHALYCRWMRVHGKVPSHLLRSKITKPNVYHESKLAAK
EYQAAKARLFTAFIKAGLGAWVEKPTEQDQFSLT
Ligand information
>7kfn Chain C (length=23) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
cagagccccccagcaucgcgagc
.......................
Receptor-Ligand Complex Structure
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PDB7kfn Rational Design of RNA Editing Guide Strands: Cytidine Analogs at the Orphan Position.
Resolution2.5 Å
Binding residue
(original residue number in PDB)		R348 I456 F457 H471 R474 R477 R481 G487 E488 I491 P492 R510 G593 K594
Binding residue
(residue number reindexed from 1)		R32 I140 F141 H155 R158 R161 R165 G171 E172 I175 P176 R194 G277 K278
Enzymatic activity
Enzyme Commision number 3.5.4.37: double-stranded RNA adenine deaminase.
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0004000 adenosine deaminase activity
Biological Process
GO:0006396 RNA processing

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Molecular Function
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Biological Process
External links
PDB RCSB:7kfn, PDBe:7kfn, PDBj:7kfn
PDBsum7kfn
PubMed33939417
UniProtP78563|RED1_HUMAN Double-stranded RNA-specific editase 1 (Gene Name=ADARB1)

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