Structure of PDB 7kcx Chain A Binding Site BS02

Receptor Information
>7kcx Chain A (length=361) Species: 93062 (Staphylococcus aureus subsp. aureus COL) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QATNSDVTPVQAANQYGYAGLSAAYEPTSAVNVSQTGQLLYQYNIDTKWN
PASMTKLMTMYLTLEAVNKGQLSLDDTVTMTNKEYIMSTLPELSNTKLYP
GQVWTIADLLQITVSNSSNAAALILAKKVSKNTSDFVDLMNNKAKAIGMK
NTHFVNPTGAENSRLRTFAPTKYKDQELTVTTARDYAILDLHVIKETPKI
LDFTKQLAPTTHAVTYYTFNFSLEGAKMSLPGTDGLKTGSSDTANYNHTI
TTKRGKFRINQVIMGAGDYKNLGGEKQRNMMGNALMERSFDQYKYVKILS
KGEQRINGKKYYVENDLYDVLPSDFSKKDYKLVVEDGKVHADYPREFINK
DYGPPTVEVHQ
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain7kcx Chain A Residue 404 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7kcx PBP4-mediated beta-lactam resistance among clinical strains of Staphylococcus aureus.
Resolution1.62 Å
Binding residue
(original residue number in PDB)		H362 D364
Binding residue
(residue number reindexed from 1)		H340 D342
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0008800 beta-lactamase activity
GO:0009002 serine-type D-Ala-D-Ala carboxypeptidase activity
Biological Process
GO:0006508 proteolysis
GO:0030655 beta-lactam antibiotic catabolic process
GO:0046677 response to antibiotic

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Molecular Function
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Biological Process
External links
PDB RCSB:7kcx, PDBe:7kcx, PDBj:7kcx
PDBsum7kcx
PubMed34151961
UniProtA0A0H2WY27

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