Structure of PDB 7kcw Chain A Binding Site BS02

Receptor Information
>7kcw Chain A (length=360) Species: 93062 (Staphylococcus aureus subsp. aureus COL) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ATNSDVTPVQAANQYGYAGLSAAYEPTSAVNVSQTGQLLYQYNIDTKWNP
ASMTKLMTMYLTLEAVNKGQLSLDDTVTMTNKEYIMSTLPELSNTKLYPG
QVWTIADLLQITVSNSSNAAALILAKKVSKNTSDFVDLMNNKAKAIGMKN
THFVNPTGAENSRLRTFAPTKYKDQELTVTTARDYAILDLHVIKETPKIL
DFTKQLAPTTHAVTYYTFNFSLEGAKMSLPGTDGLKTGSSDTANYNHTIT
TKRGKFRINQVIMGAGDYKNLGGEKQRNMMGNALMERSFDQYKYVKILSK
GEQRINGKKYYVENDLYDVLPSDFSKKDYKLVVEDGKVHADYPREFINKD
YGPPTVEVHQ
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain7kcw Chain A Residue 404 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7kcw PBP4-mediated beta-lactam resistance among clinical strains of Staphylococcus aureus.
Resolution1.73 Å
Binding residue
(original residue number in PDB)		H362 D364
Binding residue
(residue number reindexed from 1)		H339 D341
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0008800 beta-lactamase activity
GO:0009002 serine-type D-Ala-D-Ala carboxypeptidase activity
Biological Process
GO:0006508 proteolysis
GO:0030655 beta-lactam antibiotic catabolic process
GO:0046677 response to antibiotic

View graph for
Molecular Function
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Biological Process
External links
PDB RCSB:7kcw, PDBe:7kcw, PDBj:7kcw
PDBsum7kcw
PubMed34151961
UniProtA0A0H2WY27

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