Structure of PDB 7k98 Chain A Binding Site BS02

Receptor Information
>7k98 Chain A (length=343) Species: 83332 (Mycobacterium tuberculosis H37Rv) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NAMLSPEALTTAVDAAQQAIALADTLDVLARVKTEHLGDRSPLALARQAL
AVLPKEQRAEAGKRVNAARNAAQRSYDERLATLRAERDAAVLVAEGIDVT
LPSTRVPAGARHPIIMLAEHVADTFIAMGWELAEGPEVETEQFNFDALNF
PADHPARGEQDTFYIAPEDSRQLLRTHTSPVQIRTLLARELPVYIISIGR
TFRTDELDATHTPIFHQVEGLAVDRGLSMAHLRGTLDAFARAEFGPSART
RIRPHFFPFTEPSAEVDVWFANKIGGAAWVEWGGCGMVHPNVLRATGIDP
DLYSGFAFGMGLERTLQFRNGIPDMRDMVEGDVRFSLPFGVGA
Ligand information
>7k98 Chain F (length=77) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ggccagguagcucagucgguaugagcguccgccugaaaagcggaaggucg
gcgguucgaucccgccccuggccacca
<<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<
<<<<.......>>>>>>>>>>>>....
Receptor-Ligand Complex Structure
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PDB7k98 Mycobacterium tuberculosis Phe-tRNA synthetase: structural insights into tRNA recognition and aminoacylation.
Resolution2.19 Å
Binding residue
(original residue number in PDB)		T32 R45 Q46 L48 A49 R56 G60 K61 N64
Binding residue
(residue number reindexed from 1)		T34 R47 Q48 L50 A51 R58 G62 K63 N66
Enzymatic activity
Enzyme Commision number 6.1.1.20: phenylalanine--tRNA ligase.
Gene Ontology
Molecular Function
GO:0000049 tRNA binding
GO:0000166 nucleotide binding
GO:0000287 magnesium ion binding
GO:0004812 aminoacyl-tRNA ligase activity
GO:0004826 phenylalanine-tRNA ligase activity
GO:0005524 ATP binding
GO:0046872 metal ion binding
Biological Process
GO:0006412 translation
GO:0006432 phenylalanyl-tRNA aminoacylation
GO:0043039 tRNA aminoacylation
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane

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Biological Process
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Cellular Component
External links
PDB RCSB:7k98, PDBe:7k98, PDBj:7k98
PDBsum7k98
PubMed33885823
UniProtP9WFU3|SYFA_MYCTU Phenylalanine--tRNA ligase alpha subunit (Gene Name=pheS)

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