Structure of PDB 7k66 Chain A Binding Site BS02

Receptor Information
>7k66 Chain A (length=1265) Species: 9606,9823 [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AIRRYYLGAVELSWDYRQSELLRELHVDTRFPATAPSVLYKKTVFVEFTD
QLFSVARPRPPWMGLLGPTIQAEVYDTVVVTLKNMASHPVSLHAVGVSFW
KSSEGAEYEDHTSQREKEDDKVLPGKSQTYVWQVLKENGPTASDPPCLTY
SYLSHVDLVKDLNSGLIGALLVCREGSLTRERTQNLHEFVLLFAVFDEGK
SWHSAAQPAMHTVNGYVNRSLPGLIGCHKKSVYWHVIGMGTSPEVHSIFL
EGHTFLVRHHRQASLEISPLTFLTAQTFLMDLGQFLLFCHISSHHHGGME
AHVRVESCAEDGDDVSPFIQIRSVAKKHPKTWVHYIAAEEEDWDYAPLVL
APDDRSYKSQYLNNGPQRIGRKYKKVRFMAYTDETFKTREAIQHESGILG
PLLYGEVGDTLLIIFKNQASRPYNIYPHGITDVRPLYSRRLPKGVKHLKD
FPILPGEIFKYKWTVTVEDGPTKSDPRCLTRYYSSFVNMERDLASGLIGP
LLICYKESDKRNVILFSVFDENRSWYLTENIQRFLPNPAGVQLEDPEFQA
SNIMHSINGYVFDSLQLSVCLHEVAYWYILSIGAQTDFLSVFFSGYTFKH
KMVYEDTLTLFPFSGETVFMSMENPGLWILGCHNSDFRNRGMTALLKVSS
CKRTRHYFIAAVEQLWDYGMSESVPRFKKVVFREFADGSFTQPSYRGELN
KHLGLLGPYIRAEVEDNIMVTFKNQASRPYSFYSSLISYPDDQEQGAEPR
HNFVQPNETRTYFWKVQHHMAPTEDEFDCKAWAYFSDVDLEKDVHSGLIG
PLLICRANTLNAAHGRQVTVQEFALFFTIFDETKSWYFTENVERNCTLKE
NYRFHAINGYVMDTLPGLVMAQNQRIRWYLLSMGSNENIHSIHFSGHVFS
VRKKEEYKMAVYNLYPGVFETVEMLPSKVGIWRIECLIGEHLQAGMSTTF
LVYSKKCQTPLGMASGHIRDFQITASGQYGQWAPKLARLHYSGSINAWST
KEPFSWIKVDLLAPMIIHGIKTQGARQKFSSLYISQFIIMYSLDGKKWQT
YRGNSTGTLMVFFGNVDSSGIKHNIFNPPIIARYIRLHPTHYSIRSTLRM
ELMGCDLNSCSMPLGMESKAISDAQITASSYFTNMFATWSPSKARLHLQG
RSNAWRPQVNNPKEWLQVDFQKTMKVTGVTTQGVKSLLTSMYVKEFLISS
SQDGHQWTLFFQNGKVKVFQGNQDSFTPVVNSLDPPLLTRYLRIHPQSWV
HQIALRMEVLGCEAQ
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain7k66 Chain A Residue 2403 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7k66 Structure of blood coagulation factor VIII in complex with an anti-C1 domain pathogenic antibody inhibitor.
Resolution3.92 Å
Binding residue
(original residue number in PDB)		K108 E123 D126 D127
Binding residue
(residue number reindexed from 1)		K101 E116 D119 D120
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005507 copper ion binding
GO:0016491 oxidoreductase activity

View graph for
Molecular Function
External links
PDB RCSB:7k66, PDBe:7k66, PDBj:7k66
PDBsum7k66
PubMed33529335
UniProtP00451|FA8_HUMAN Coagulation factor VIII (Gene Name=F8);
P12263|FA8_PIG Coagulation factor VIII (Gene Name=F8)

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